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The triumvirate: why hypertension, obesity, and diabetes are risk factors for adverse effects in patients with COVID-19.
Shah, Harsh; Khan, Md Shahjalal Hossain; Dhurandhar, Nikhil V; Hegde, Vijay.
  • Shah H; Obesity and Metabolic Health Laboratory, Department of Nutritional Sciences, Texas Tech University, 1301 Akron Ave, Lubbock, TX, 79409, USA.
  • Khan MSH; Obesity and Metabolic Health Laboratory, Department of Nutritional Sciences, Texas Tech University, 1301 Akron Ave, Lubbock, TX, 79409, USA.
  • Dhurandhar NV; Obesity and Metabolic Health Laboratory, Department of Nutritional Sciences, Texas Tech University, 1301 Akron Ave, Lubbock, TX, 79409, USA.
  • Hegde V; Obesity and Metabolic Health Laboratory, Department of Nutritional Sciences, Texas Tech University, 1301 Akron Ave, Lubbock, TX, 79409, USA. vijay.hegde@ttu.edu.
Acta Diabetol ; 58(7): 831-843, 2021 Jul.
Article in English | MEDLINE | ID: covidwho-1083870
ABSTRACT
The outbreak of coronavirus disease 2019 (COVID-19) caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a pandemic. The cellular receptor for SARS-CoV-2 entry is the angiotensin-converting enzyme 2, a membrane-bound homolog of angiotensin-converting enzyme. Henceforth, this has brought the attention of the scientific community to study the interaction between COVID-19 and the renin-angiotensin system (RAS), as well as RAS inhibitors. However, these inhibitors are commonly used to treat hypertension, chronic kidney disorder, and diabetes. Obesity is a known risk factor for heart disease, diabetes, and hypertension, whereas diabetes and hypertension may be indirectly related to each other through the effects of obesity. Furthermore, people with hypertension, obesity, diabetes, and other related complications like cardiovascular and kidney diseases have a higher risk of severe COVID-19 infection than the general population and usually exhibit poor prognosis. This severity could be due to systemic inflammation and compromised immune response and RAS associated with these comorbid conditions. Therefore, there is an urgent need to develop evidence-based treatment methods that do not affect the severity of COVID-19 infection and effectively manage these chronic diseases in people with COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Diabetes Mellitus / COVID-19 / Hypertension / Obesity Type of study: Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Acta Diabetol Journal subject: Endocrinology Year: 2021 Document Type: Article Affiliation country: S00592-020-01636-z

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Diabetes Mellitus / COVID-19 / Hypertension / Obesity Type of study: Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Acta Diabetol Journal subject: Endocrinology Year: 2021 Document Type: Article Affiliation country: S00592-020-01636-z