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Neurological involvement in the respiratory manifestations of COVID-19 patients.
Tan, Bai-Hong; Liu, Jia-Mei; Gui, Yue; Wu, Shuang; Suo, Jia-Le; Li, Yan-Chao.
  • Tan BH; Laboratory Teaching Center of Basic Medicine, Norman Bethune Health Science Center of Jilin University, Jilin, China.
  • Liu JM; Department of Histology and Embryology, College of Basic Medical Sciences, Norman Bethune College of Medicine, Jilin University, Changchun, Jilin, China.
  • Gui Y; Department of Histology and Embryology, College of Basic Medical Sciences, Norman Bethune College of Medicine, Jilin University, Changchun, Jilin, China.
  • Wu S; Department of Histology and Embryology, College of Basic Medical Sciences, Norman Bethune College of Medicine, Jilin University, Changchun, Jilin, China.
  • Suo JL; Department of Histology and Embryology, College of Basic Medical Sciences, Norman Bethune College of Medicine, Jilin University, Changchun, Jilin, China.
  • Li YC; Department of Histology and Embryology, College of Basic Medical Sciences, Norman Bethune College of Medicine, Jilin University, Changchun, Jilin, China.
Aging (Albany NY) ; 13(3): 4713-4730, 2021 02 14.
Article in English | MEDLINE | ID: covidwho-1084188
ABSTRACT
The peculiar features of coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), are challenging the current biological knowledge. Early in Feb, 2020, we suggested that SARS-CoV-2 may possess neuroinvasive potential similar to that of many other coronaviruses. Since then, a variety of neurological manifestations have been associated with SARS-CoV-2 infection, which was supported in some patients with neuroimaging and/or cerebrospinal fluid tests. To date, at least 27 autopsy studies on the brains of COVID-19 patients can be retrieved through PubMed/MEDLINE, among which neuropathological alterations were observed in the brainstem in 78 of 134 examined patients, and SARS-CoV-2 nucleic acid and viral proteins were detected in the brainstem in 16/49 (32.7%) and 18/71 (25.3%) cases, respectively. To shed some light on the peculiar respiratory manifestations of COVID-19 patients, this review assessed the existing evidence about the neurogenic mechanism underlying the respiratory failure induced by SARS-CoV-2 infection. Acknowledging the neurological involvement has important guiding significance for the prevention, treatment, and prognosis of SARS-CoV-2 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 / Nervous System Diseases Type of study: Diagnostic study / Prognostic study / Reviews Limits: Humans Language: English Journal: Aging (Albany NY) Journal subject: Geriatrics Year: 2021 Document Type: Article Affiliation country: Aging.202665

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 / Nervous System Diseases Type of study: Diagnostic study / Prognostic study / Reviews Limits: Humans Language: English Journal: Aging (Albany NY) Journal subject: Geriatrics Year: 2021 Document Type: Article Affiliation country: Aging.202665