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The Neutralizing Antibody Response against Severe Acute Respiratory Syndrome Coronavirus 2 and the Cytokine/Chemokine Release in Patients with Different Levels of Coronavirus Diseases 2019 Severity: Cytokine Storm Still Persists Despite Viral Disappearance in Critical Patients.
Tjan, Lidya Handayani; Nagano, Tatsuya; Furukawa, Koichi; Nishimura, Mitsuhiro; Arii, Jun; Fujinaka, Sayo; Iwata, Sachiyo; Sano, Shigeru; Tohma, Yoshiki; Nishimura, Yoshihiro; Mori, Yasuko.
  • Tjan LH; Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Nagano T; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Furukawa K; Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Nishimura M; Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Arii J; Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Fujinaka S; Clinical Laboratory Department, Hyogo Prefectural Kakogawa Medical Center, Kakogawa, Japan.
  • Iwata S; Division of Cardiovascular Medicine, Hyogo Prefectural Kakogawa Medical Center, Kakogawa, Japan.
  • Sano S; Acute Care Medical Center, Hyogo Prefectural Kakogawa Medical Center, Kakogawa, Japan.
  • Tohma Y; Acute Care Medical Center, Hyogo Prefectural Kakogawa Medical Center, Kakogawa, Japan.
  • Nishimura Y; Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Mori Y; Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Japan.
JMA J ; 4(1): 1-7, 2021 Jan 29.
Article in English | MEDLINE | ID: covidwho-1084276
Semantic information from SemMedBD (by NLM)
1. 2019 novel coronavirus PROCESS_OF Patients
Subject
2019 novel coronavirus
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PROCESS_OF
Object
Patients
2. Cytokine Storm PROCESS_OF Patients
Subject
Cytokine Storm
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PROCESS_OF
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Patients
3. COVID-19 PROCESS_OF Patients
Subject
COVID-19
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PROCESS_OF
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Patients
4. Antibodies CAUSES High Level
Subject
Antibodies
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CAUSES
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High Level
5. High Level PROCESS_OF Patients
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High Level
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PROCESS_OF
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Patients
6. Steroid therapy TREATS Symptom severe
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TREATS
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Symptom severe
7. Symptom severe PROCESS_OF Patients
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Symptom severe
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PROCESS_OF
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Patients
8. Antiviral Therapy TREATS Virus
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Antiviral Therapy
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TREATS
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Virus
9. Steroid therapy TREATS Patients
Subject
Steroid therapy
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TREATS
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Patients
10. 2019 novel coronavirus PROCESS_OF Patients
Subject
2019 novel coronavirus
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PROCESS_OF
Object
Patients
11. Cytokine Storm PROCESS_OF Patients
Subject
Cytokine Storm
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PROCESS_OF
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Patients
12. COVID-19 PROCESS_OF Patients
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COVID-19
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13. Antibodies CAUSES High Level
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Antibodies
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High Level
14. High Level PROCESS_OF Patients
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15. Steroid therapy TREATS Symptom severe
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17. Antiviral Therapy TREATS Virus
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18. Steroid therapy TREATS Patients
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ABSTRACT
Patients with coronavirus disease 2019 (COVID-19) exhibit a wide clinical spectrum ranging from mild respiratory symptoms to critical and fatal diseases, and older individuals are known to be more severely affected. The underlying mechanism of this phenomenon is unknown. A neutralizing antibody against viruses is known to be important to eliminate the virus. In addition, this antibody is induced at high levels in patients with severe COVID-19, followed by a termination of virus replication. Severe COVID-19 patients exhibit high levels of cytokines/chemokines, even after the disappearance of the virus. This indicates that cytokines/chemokines play significant roles in disease severity. These findings also suggest that antiviral therapy (monoclonal antibody and/or convalescent plasma therapy) should be administered early to eliminate the virus, followed by steroid treatment after viral genome disappearance, especially in patients with severe symptoms.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Long Covid Language: English Journal: JMA J Year: 2021 Document Type: Article Affiliation country: Jmaj.2020-0083

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Long Covid Language: English Journal: JMA J Year: 2021 Document Type: Article Affiliation country: Jmaj.2020-0083