Your browser doesn't support javascript.
Clinical outcomes of different therapeutic options for COVID-19 in two Chinese case cohorts: A propensity-score analysis.
Wong, Carlos K H; Wan, Eric Y F; Luo, Sihui; Ding, Yu; Lau, Eric H Y; Ling, Ping; Hu, Xiaowen; Lau, Edward C H; Wong, Jerry; Zheng, Xueying; Cowling, Benjamin J; Weng, Jianping; Leung, Gabriel M.
  • Wong CKH; Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Wan EYF; Department of Family Medicine and Primary Care, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Luo S; Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Ding Y; Department of Family Medicine and Primary Care, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Lau EHY; The First Affiliation Hospital of University of Science and Technology (Anhui Provincial Hospital), Hefei, Anhui, China.
  • Ling P; Institute of Public Health, University of Science and Technology of China, Hefei, Anhui, China.
  • Hu X; The First Affiliation Hospital of University of Science and Technology (Anhui Provincial Hospital), Hefei, Anhui, China.
  • Lau ECH; Institute of Public Health, University of Science and Technology of China, Hefei, Anhui, China.
  • Wong J; WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Zheng X; Laboratory of Data Discovery for Health (D24H), Hong Kong Science and Technology Park, Hong Kong SAR, China.
  • Cowling BJ; The First Affiliation Hospital of University of Science and Technology (Anhui Provincial Hospital), Hefei, Anhui, China.
  • Weng J; Institute of Public Health, University of Science and Technology of China, Hefei, Anhui, China.
  • Leung GM; The First Affiliation Hospital of University of Science and Technology (Anhui Provincial Hospital), Hefei, Anhui, China.
EClinicalMedicine ; 32: 100743, 2021 Feb.
Article in English | MEDLINE | ID: covidwho-1084574
ABSTRACT

BACKGROUND:

The timing of administration of agents and use of combination treatments in COVID-19 remain unclear. We assessed the effectiveness of therapeutics in cohorts in Hong Kong SAR and Anhui, China.

METHODS:

We conducted propensity-score analysis of 4771 symptomatic patients from Hong Kong between 21st January and 6th December 2020, and 648 symptomatic patients from Anhui between 1st January and 27th February 2020. We censored all observations as at 13st December 2020. Time from hospital admission to discharge, and composite outcome of death, invasive mechanical ventilation or intensive care unit admission across 1) all therapeutic options including lopinavir-ritonavir, ribavirin, umifenovir, interferon-alpha-2b, interferon-beta-1b, corticosteroids, antibiotics, and Chinese medicines, and 2) four interferon-beta-1b combination treatment groups were investigated.

FINDINGS:

Interferon-beta-1b was associated with an improved composite outcome (OR=0.55, 95%CI 0.38, 0.80) and earlier discharge (-8.8 days, 95%CI -9.7, -7.9) compared to those not administered interferon-beta-1b. Oral ribavirin initiated within 7 days from onset was associated with lower risk of the composite outcome in Hong Kong (OR=0.51, 95%CI 0.29, 0.90). Lopinavir-ritonavir, intravenous ribavirin, umifenovir, corticosteroids, interferon-alpha-2b, antibiotics or Chinese medicines failed to show consistent clinical benefit. Interferon-beta-1b co-administered with ribavirin was associated with improved composite outcome (OR=0.50, 95%CI 0.32, 0.78) and earlier discharge (-2.35 days, 95%CI -3.65, -1.06) compared to interferon-beta-1b monotherapy.

INTERPRETATION:

Our findings support the early administration of interferon-beta-1b alone or in combination with oral ribavirin for COVID-19 patients.

FUNDING:

Hong Kong Health and Medical Research Fund; Hong Kong Innovation and Technology Commission; Chinese Fundamental Research Funds for the Central Universities.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Journal: EClinicalMedicine Year: 2021 Document Type: Article Affiliation country: J.eclinm.2021.100743

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Journal: EClinicalMedicine Year: 2021 Document Type: Article Affiliation country: J.eclinm.2021.100743