Your browser doesn't support javascript.
Nucleoside Analogs and Nucleoside Precursors as Drugs in the Fight against SARS-CoV-2 and Other Coronaviruses.
Borbone, Nicola; Piccialli, Gennaro; Roviello, Giovanni Nicola; Oliviero, Giorgia.
  • Borbone N; Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy.
  • Piccialli G; Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy.
  • Roviello GN; Institute of Biostructures and Bioimaging-CNR 1, Via Mezzocannone 16, 80134 Naples, Italy.
  • Oliviero G; Department of Molecular Medicine and Medical Biotechnologies, University of Napoli Federico II, Via Sergio Pansini 5, 80131 Naples, Italy.
Molecules ; 26(4)2021 Feb 13.
Article in English | MEDLINE | ID: covidwho-1085052
ABSTRACT
Coronaviruses (CoVs) are positive-sense RNA enveloped viruses, members of the family Coronaviridae, that cause infections in a broad range of mammals including humans. Several CoV species lead to mild upper respiratory infections typically associated with common colds. However, three human CoV (HCoV) species Severe Acute Respiratory Syndrome (SARS)-CoV-1, Middle East Respiratory Syndrome (MERS)-CoV, and SARS-CoV-2, are responsible for severe respiratory diseases at the origin of two recent epidemics (SARS and MERS), and of the current COronaVIrus Disease 19 (COVID-19), respectively. The easily transmissible SARS-CoV-2, emerging at the end of 2019 in China, spread rapidly worldwide, leading the World Health Organization (WHO) to declare COVID-19 a pandemic. While the world waits for mass vaccination, there is an urgent need for effective drugs as short-term weapons to combat the SARS-CoV-2 infection. In this context, the drug repurposing approach is a strategy able to guarantee positive results rapidly. In this regard, it is well known that several nucleoside-mimicking analogs and nucleoside precursors may inhibit the growth of viruses providing effective therapies for several viral diseases, including HCoV infections. Therefore, this review will focus on synthetic nucleosides and nucleoside precursors active against different HCoV species, paying great attention to SARS-CoV-2. This work covers progress made in anti-CoV therapy with nucleoside derivatives and provides insight into their main mechanisms of action.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Severe Acute Respiratory Syndrome / Severe acute respiratory syndrome-related coronavirus / Drug Repositioning / SARS-CoV-2 / COVID-19 Drug Treatment / Nucleosides Type of study: Observational study Topics: Vaccines Limits: Animals / Humans Language: English Journal subject: Biology Year: 2021 Document Type: Article Affiliation country: Molecules26040986

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Severe Acute Respiratory Syndrome / Severe acute respiratory syndrome-related coronavirus / Drug Repositioning / SARS-CoV-2 / COVID-19 Drug Treatment / Nucleosides Type of study: Observational study Topics: Vaccines Limits: Animals / Humans Language: English Journal subject: Biology Year: 2021 Document Type: Article Affiliation country: Molecules26040986