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Sinus Bradycardia Associated with Remdesivir Treatment in COVID-19: A Case Report and Literature Review.
Barkas, Fotios; Styla, Chrysoula-Paraskevi; Bechlioulis, Aris; Milionis, Haralampos; Liberopoulos, Evangelos.
  • Barkas F; Department of Internal Medicine, University Hospital of Ioannina, 45110 Ioannina, Greece.
  • Styla CP; Department of Internal Medicine, University Hospital of Ioannina, 45110 Ioannina, Greece.
  • Bechlioulis A; Department of Cardiology, University Hospital of Ioannina, 45110 Ioannina, Greece.
  • Milionis H; Department of Internal Medicine, University Hospital of Ioannina, 45110 Ioannina, Greece.
  • Liberopoulos E; Department of Internal Medicine, University Hospital of Ioannina, 45110 Ioannina, Greece.
J Cardiovasc Dev Dis ; 8(2)2021 Feb 12.
Article in English | MEDLINE | ID: covidwho-1085069
ABSTRACT

BACKGROUND:

Although remdesivir treatment is widely used during the pandemic coronavirus disease 2019 (COVID-19), there is scarce evidence regarding its cardiac side effects. CASE PRESENTATION We report the case of a 36-year-old male hospitalized due to severe COVID-19 symptoms. He presented with a 10-day history of fever (up to 39.7 °C), productive cough, hemoptysis, fatigue, myalgias and hypoxemia. The patient received supplemental oxygen, dexamethasone, remdesivir and empirical antibiotic treatment according to protocol. Asymptomatic sinus bradycardia developed on hospital day 3 (namely, heart rate 39/min compared to 92/min on admission). Secondary causes of bradycardia were excluded based on the absence of relevant evidence from laboratory work-up and echocardiographic examination. The patient's rhythm restored to normal 9 days after the discontinuation of remdesivir.

CONCLUSIONS:

Considering the frequent use of remdesivir in patients with COVID-19, physicians should be aware of this possible adverse event.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Prognostic study / Reviews Language: English Year: 2021 Document Type: Article Affiliation country: Jcdd8020018

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Prognostic study / Reviews Language: English Year: 2021 Document Type: Article Affiliation country: Jcdd8020018