Potential intestinal infection and faecal-oral transmission of SARS-CoV-2.
Nat Rev Gastroenterol Hepatol
; 18(4): 269-283, 2021 04.
Article
in English
| MEDLINE | ID: covidwho-1085424
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread to more than 200 countries and regions globally. SARS-CoV-2 is thought to spread mainly through respiratory droplets and close contact. However, reports have shown that a notable proportion of patients with coronavirus disease 2019 (COVID-19) develop gastrointestinal symptoms and nearly half of patients confirmed to have COVID-19 have shown detectable SARS-CoV-2 RNA in their faecal samples. Moreover, SARS-CoV-2 infection reportedly alters intestinal microbiota, which correlated with the expression of inflammatory factors. Furthermore, multiple in vitro and in vivo animal studies have provided direct evidence of intestinal infection by SARS-CoV-2. These lines of evidence highlight the nature of SARS-CoV-2 gastrointestinal infection and its potential faecal-oral transmission. Here, we summarize the current findings on the gastrointestinal manifestations of COVID-19 and its possible mechanisms. We also discuss how SARS-CoV-2 gastrointestinal infection might occur and the current evidence and future studies needed to establish the occurrence of faecal-oral transmission.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Vomiting
/
Diarrhea
/
Dysbiosis
/
Gastrointestinal Microbiome
/
Gastroenteritis
/
COVID-19
/
Nausea
Limits:
Animals
/
Humans
Language:
English
Journal:
Nat Rev Gastroenterol Hepatol
Journal subject:
Gastroenterology
Year:
2021
Document Type:
Article
Affiliation country:
S41575-021-00416-6
Similar
MEDLINE
...
LILACS
LIS