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Anti-spike S1 receptor-binding domain antibodies against SARS-CoV-2 persist several months after infection regardless of disease severity.
Bavaro, Davide F; Laghetti, Paola; Milano, Eugenio; Brindicci, Gaetano; Volpe, Anna; Lagioia, Antonella; Saracino, Annalisa; Monno, Laura.
  • Bavaro DF; Clinic of Infectious Diseases, University Hospital Policlinico, University of Bari, Bari, Italy.
  • Laghetti P; Clinic of Infectious Diseases, University Hospital Policlinico, University of Bari, Bari, Italy.
  • Milano E; Clinic of Infectious Diseases, University Hospital Policlinico, University of Bari, Bari, Italy.
  • Brindicci G; Clinic of Infectious Diseases, University Hospital Policlinico, University of Bari, Bari, Italy.
  • Volpe A; Clinic of Infectious Diseases, University Hospital Policlinico, University of Bari, Bari, Italy.
  • Lagioia A; Clinic of Infectious Diseases, University Hospital Policlinico, University of Bari, Bari, Italy.
  • Saracino A; Clinic of Infectious Diseases, University Hospital Policlinico, University of Bari, Bari, Italy.
  • Monno L; Clinic of Infectious Diseases, University Hospital Policlinico, University of Bari, Bari, Italy.
J Med Virol ; 93(5): 3158-3164, 2021 May.
Article in English | MEDLINE | ID: covidwho-1085668
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
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COVID-19
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2. Disease PROCESS_OF Patients
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3. COVID-19 PROCESS_OF Patients
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COVID-19
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4. Disease PROCESS_OF Patients
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ABSTRACT
Data regarding the immunological memory and long-time kinetics of immunoglobulin (IgG) against viral nucleoprotein (NP) and spike protein S1 receptor-binding domain (S1RBD) of Severe Acute Respiratory Syndrome-associated Coronavirus 2 (SARS-CoV-2) are lacking. All consecutive COVID-19 patients admitted to our Clinic between March 1, 2020, and May 1, 2020, who were tested at hospital admission for anti-S1RBD and anti-NP IgG were enrolled. Serum samples were tested for anti-SARS-CoV-2 antibodies with the use of two commercially available enzyme-linked immunosorbent assays. Results are expressed as optical density measurements at 450 nm (OD450 ). Overall, 111 patients were included; the median (q1-q3) age was 57 (49-73) years, 59 (53%) males. According to disease severity, 31 (28%), 47 (42%), and 33 (30%) patients were considered affected by mild/moderate, severe, and critical SARS-CoV-2 infection, respectively. During hospitalization, patients with the critical disease showed a higher peak value of both anti-NP (median OD450 3.66 vs. 3.06 vs. 3.00 respectively, p = .043) and anti-S1RBD IgG (median OD450 2.33 vs. 1.6 vs. 0.91, respectively, p < .001). By testing 48 subjects 6 months or above from discharge, a significant decrease of anti-NP IgG was observed (r -0.5838; p < .0001), whereas anti-S1RBD IgG showed only a modest reduction (r -0.1507; p = .0647). Accordingly, 10 (21%) and 2 (4%) patients had a negative serological status for anti-NP and anti-S1RBD IgG, respectively; no association with clinical severity was found. IgGs against SARS-CoV-2 persisted several months after discharge, regardless of disease severity, suggesting that vaccination could be a valid strategy to fight the pandemic.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Spike Glycoprotein, Coronavirus / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Prognostic study Topics: Vaccines Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: J Med Virol Year: 2021 Document Type: Article Affiliation country: Jmv.26878

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Spike Glycoprotein, Coronavirus / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Prognostic study Topics: Vaccines Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: J Med Virol Year: 2021 Document Type: Article Affiliation country: Jmv.26878