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Rate and predictive parameters of novel Coronavirus 2019 (Sars-CoV-2) infections in a German General Practice.
Paar, Moritz; Strumann, Christoph; Giesen, Heinz.
  • Paar M; University Hospital Münster, Münster, Germany. paarm@uni-muenster.de.
  • Strumann C; General Practice Dr. Dr. Giesen, Ahaus-Wüllen, Germany. paarm@uni-muenster.de.
  • Giesen H; University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.
Ir J Med Sci ; 191(1): 31-37, 2022 Feb.
Article in English | MEDLINE | ID: covidwho-1086658
Semantic information from SemMedBD (by NLM)
1. Laboratory Procedures USES Immunoglobulin M|CD40LG
Subject
Laboratory Procedures
Predicate
USES
Object
Immunoglobulin M|CD40LG
2. Infected PROCESS_OF Persons
Subject
Infected
Predicate
PROCESS_OF
Object
Persons
3. Influenza-like symptoms PROCESS_OF Adult
Subject
Influenza-like symptoms
Predicate
PROCESS_OF
Object
Adult
4. Influenza-like symptoms PROCESS_OF Child
Subject
Influenza-like symptoms
Predicate
PROCESS_OF
Object
Child
5. COVID-19 PROCESS_OF Adult
Subject
COVID-19
Predicate
PROCESS_OF
Object
Adult
6. COVID-19 PROCESS_OF Child
Subject
COVID-19
Predicate
PROCESS_OF
Object
Child
7. Diagnosis DIAGNOSES Asymptomatic Infections
Subject
Diagnosis
Predicate
DIAGNOSES
Object
Asymptomatic Infections
8. Laboratory Procedures USES Immunoglobulin M|CD40LG
Subject
Laboratory Procedures
Predicate
USES
Object
Immunoglobulin M|CD40LG
9. Infected PROCESS_OF Persons
Subject
Infected
Predicate
PROCESS_OF
Object
Persons
10. Influenza-like symptoms PROCESS_OF Adult
Subject
Influenza-like symptoms
Predicate
PROCESS_OF
Object
Adult
11. Influenza-like symptoms PROCESS_OF Child
Subject
Influenza-like symptoms
Predicate
PROCESS_OF
Object
Child
12. COVID-19 PROCESS_OF Adult
Subject
COVID-19
Predicate
PROCESS_OF
Object
Adult
13. COVID-19 PROCESS_OF Child
Subject
COVID-19
Predicate
PROCESS_OF
Object
Child
14. Diagnosis DIAGNOSES Asymptomatic Infections
Subject
Diagnosis
Predicate
DIAGNOSES
Object
Asymptomatic Infections
ABSTRACT
KEY POINTS In our clinical cross-sectional study, we identified 107 of 347 patients who were tested positive for antibodies of novel Coronavirus 2019 (SARS-CoV-2). Main symptoms were exhaustion and cough, exposition to other COVID-19-patients appeared frequently.

BACKGROUND:

There is urgent need for information on predictive parameters on immunity and infectivity in Coronavirus disease-2019 (COVID-19) pandemic. Our aim was to investigate distribution of novel Coronavirus 2019 (SARS-CoV-2) infections in a German General Practice and to learn about possible predictive parameters regarding infection and pathways of transmission.

METHODS:

In our cross-sectional study, we tested 347 patients of our General Practice using 2019-nCoV-2-IgG/IgM antibody test [2019-nCoV2 IgG/IgM Rapid Test Cassette (Ref. INCP-402/INCP-402B; ACRO, BIOTECH, INC.)]. We asked for 13 specific symptoms and 4 questions to investigate patients' surroundings.

RESULTS:

A total of 107 of 347 patients were tested positive for antibodies (Immunoglobulin M-positive and/or Immunoglobulin G-positive). In antibody-positive group, body aches and rhinorrhea were seen more often and there were significantly less asymptomatic patients. Stay in area of risk was significantly more frequent in antibody-positive group as well as contact to infected persons. Distribution of other symptoms was not significantly different between both groups. Most adults or children with SARS-CoV-2 infection presented with mild flu-like symptoms.

CONCLUSION:

A total of 30% of patients had antibodies. It was not possible to identify one solid predictive symptom. Serological testing may be helpful for the diagnosis of suspected patients with negative RT-PCR results and for the identification of asymptomatic infections.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Child / Humans Language: English Journal: Ir J Med Sci Year: 2022 Document Type: Article Affiliation country: S11845-021-02555-w

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Child / Humans Language: English Journal: Ir J Med Sci Year: 2022 Document Type: Article Affiliation country: S11845-021-02555-w