Inflammation control and improvement of cognitive function in COVID-19 infections: is there a role for kynurenine 3-monooxygenase inhibition?
Drug Discov Today
; 26(6): 1473-1481, 2021 06.
Article
in English
| MEDLINE | ID: covidwho-1086904
ABSTRACT
The novel respiratory virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), emerged during late 2019 and spread rapidly across the world. It is now recognised that the nervous system can be affected in COVID-19, with several studies reporting long-term cognitive problems in patients. The metabolic pathway of tryptophan degradation, known as the kynurenine pathway (KP), is significantly activated in patients with COVID-19. KP metabolites have roles in regulating both inflammatory/immune responses and neurological functions. In this review, we speculate on the effects of KP activation in patients with COVID-19, and how modulation of this pathway might impact inflammation and reduce neurological symptoms.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Sulfonamides
/
Thiazoles
/
Tryptophan
/
Cognition
/
COVID-19
/
Inflammation
/
Kynurenine
Type of study:
Qualitative research
Topics:
Long Covid
Limits:
Animals
/
Humans
Language:
English
Journal:
Drug Discov Today
Journal subject:
Pharmacology
/
Drug Therapy
Year:
2021
Document Type:
Article
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