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COVID-19: A methyl-group assault?
McCaddon, Andrew; Regland, Björn.
  • McCaddon A; Gardden Road Surgery, Rhosllanerchrugog Wrexham, LL14 2EN, UK. Electronic address: mccaddon@sky.com.
  • Regland B; Institute of Neuroscience and Physiology, Gothenburg University, Gothenburg, Sweden. Electronic address: bjorn.regland@gu.se.
Med Hypotheses ; 149: 110543, 2021 Apr.
Article in English | MEDLINE | ID: covidwho-1087147
ABSTRACT
The socio-economic implications of COVID-19 are devastating. Considerable morbidity is attributed to 'long-COVID' - an increasingly recognized complication of infection. Its diverse symptoms are reminiscent of vitamin B12 deficiency, a condition in which methylation status is compromised. We suggest why SARS-CoV-2 infection likely leads to increased methyl-group requirements and other disturbances of one-carbon metabolism. We propose these might explain the varied symptoms of long-COVID. Our suggested mechanismmight also apply to similar conditions such as myalgic encephalomyelitis/chronic fatigue syndrome. The hypothesis is evaluable by detailed determination of vitamin B12and folate status, including serum formate as well as homocysteine and methylmalonic acid, and correlation with viral and host RNA methylation and symptomatology. If confirmed, methyl-group support should prove beneficial in such individuals.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vitamin B 12 Deficiency / Folic Acid / COVID-19 Type of study: Diagnostic study Topics: Long Covid Limits: Humans Language: English Journal: Med Hypotheses Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vitamin B 12 Deficiency / Folic Acid / COVID-19 Type of study: Diagnostic study Topics: Long Covid Limits: Humans Language: English Journal: Med Hypotheses Year: 2021 Document Type: Article