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Impact of the coronavirus disease 2019 (COVID-19) pandemic on nosocomial Clostridioides difficile infection.
Ponce-Alonso, Manuel; Sáez de la Fuente, Javier; Rincón-Carlavilla, Angela; Moreno-Nunez, Paloma; Martínez-García, Laura; Escudero-Sánchez, Rosa; Pintor, Rosario; García-Fernández, Sergio; Cobo, Javier.
  • Ponce-Alonso M; Servicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain.
  • Sáez de la Fuente J; Red Española de Investigación en Patología Infecciosa, Madrid, Spain.
  • Rincón-Carlavilla A; Servicio de Farmacia Hospitalaria, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain.
  • Moreno-Nunez P; Servicio de Medicina Preventiva, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain.
  • Martínez-García L; Servicio de Medicina Preventiva, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain.
  • Escudero-Sánchez R; Servicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain.
  • Pintor R; Red Española de Investigación en Patología Infecciosa, Madrid, Spain.
  • García-Fernández S; Servicio de Enfermedades Infecciosas, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain.
  • Cobo J; Servicio de Farmacia Hospitalaria, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria, Madrid, Spain.
Infect Control Hosp Epidemiol ; 42(4): 406-410, 2021 04.
Article in English | MEDLINE | ID: covidwho-1087384
ABSTRACT

OBJECTIVES:

The coronavirus disease 2019 (COVID-19) pandemic has induced a reinforcement of infection control measures in the hospital setting. Here, we assess the impact of the COVID-19 pandemic on the incidence of nosocomial Clostridioides difficile infection (CDI).

METHODS:

We retrospectively compared the incidence density (cases per 10,000 patient days) of healthcare-facility-associated (HCFA) CDI in a tertiary-care hospital in Madrid, Spain, during the maximum incidence of COVID-19 (March 11 to May 11, 2020) with the same period of the previous year (control period). We also assessed the aggregate in-hospital antibiotic use (ie, defined daily doses [DDD] per 100 occupied bed days [BD]) and incidence density (ie, movements per 1,000 patient days) of patient mobility during both periods.

RESULTS:

In total, 2,337 patients with reverse transcription-polymerase chain reaction-confirmed COVID-19 were admitted to the hospital during the COVID-19 period. Also, 12 HCFA CDI cases were reported at this time (incidence density, 2.68 per 10,000 patient days), whereas 34 HCFA CDI cases were identified during the control period (incidence density, 8.54 per 10,000 patient days) (P = .000257). Antibiotic consumption was slightly higher during the COVID-19 period (89.73 DDD per 100 BD) than during the control period (79.16 DDD per 100 BD). The incidence density of patient movements was 587.61 per 1,000 patient days during the control period and was significantly lower during the COVID-19 period (300.86 per 1,000 patient days) (P < .0001).

CONCLUSIONS:

The observed reduction of ~70% in the incidence density of HCFA CDI in a context of no reduction in antibiotic use supports the importance of reducing nosocomial transmission by healthcare workers and asymptomatic colonized patients, reinforcing cleaning procedures and reducing patient mobility in the epidemiological control of CDI.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Cross Infection / Clostridium Infections / COVID-19 Type of study: Experimental Studies / Observational study / Randomized controlled trials Topics: Long Covid Limits: Aged / Humans / Middle aged Country/Region as subject: Europa Language: English Journal: Infect Control Hosp Epidemiol Journal subject: Communicable Diseases / Nursing / Epidemiology / Hospitals Year: 2021 Document Type: Article Affiliation country: Ice.2020.454

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cross Infection / Clostridium Infections / COVID-19 Type of study: Experimental Studies / Observational study / Randomized controlled trials Topics: Long Covid Limits: Aged / Humans / Middle aged Country/Region as subject: Europa Language: English Journal: Infect Control Hosp Epidemiol Journal subject: Communicable Diseases / Nursing / Epidemiology / Hospitals Year: 2021 Document Type: Article Affiliation country: Ice.2020.454