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A rapid screening model for early predicting novel coronavirus pneumonia in Zhejiang Province of China: a multicenter study.
Dai, Yi-Ning; Zheng, Wei; Wu, Qing-Qing; Hui, Tian-Chen; Sun, Nan-Nan; Chen, Guo-Bo; Tong, Yong-Xi; Bao, Su-Xia; Wu, Wen-Hao; Huang, Yi-Cheng; Yin, Qiao-Qiao; Wu, Li-Juan; Yu, Li-Xia; Shi, Ji-Chan; Fang, Nian; Shen, Yue-Fei; Xie, Xin-Sheng; Ma, Chun-Lian; Yu, Wan-Jun; Tu, Wen-Hui; Yan, Rong; Wang, Ming-Shan; Chen, Mei-Juan; Zhang, Jia-Jie; Ju, Bin; Gao, Hai-Nv; Huang, Hai-Jun; Li, Lan-Juan; Pan, Hong-Ying.
  • Dai YN; Department of Infectious Diseases, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, No. 158 Shangtang Road, Hangzhou, 310014, Zhejiang, China.
  • Zheng W; Department of Infectious Diseases, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, No. 158 Shangtang Road, Hangzhou, 310014, Zhejiang, China.
  • Wu QQ; Department of Infectious Diseases, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, No. 158 Shangtang Road, Hangzhou, 310014, Zhejiang, China.
  • Hui TC; The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
  • Sun NN; Department of Infectious Diseases, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, No. 158 Shangtang Road, Hangzhou, 310014, Zhejiang, China.
  • Chen GB; Bengbu Medical College, Bengbu, China.
  • Tong YX; Hangzhou Wowjoy Information Technology Co., Ltd, Hangzhou, China.
  • Bao SX; Clinical Research Institute, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China.
  • Wu WH; Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou, China.
  • Huang YC; Department of Infectious Diseases, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, No. 158 Shangtang Road, Hangzhou, 310014, Zhejiang, China.
  • Yin QQ; Department of Infectious Diseases, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, No. 158 Shangtang Road, Hangzhou, 310014, Zhejiang, China.
  • Wu LJ; Department of Infectious Diseases, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, No. 158 Shangtang Road, Hangzhou, 310014, Zhejiang, China.
  • Yu LX; Medical College of Qingdao University, Qingdao, China.
  • Shi JC; Department of Infectious Diseases, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, No. 158 Shangtang Road, Hangzhou, 310014, Zhejiang, China.
  • Fang N; Department of Infectious Diseases, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, No. 158 Shangtang Road, Hangzhou, 310014, Zhejiang, China.
  • Shen YF; Bengbu Medical College, Bengbu, China.
  • Xie XS; Department of Infectious Diseases, First People's Hospital of Tongxiang, Jiaxing, China.
  • Ma CL; Department of Infectious Diseases, People's Hospital of Shaoxing, Shaoxing, China.
  • Yu WJ; Department of Infectious Diseases, Wenzhou Central Hospital, Wenzhou, China.
  • Tu WH; Department of Infectious Diseases, First Hospital of Taizhou, Taizhou, China.
  • Yan R; Department of Infectious Diseases, First People's Hospital of Xiaoshan, Hangzhou, China.
  • Wang MS; Department of Infectious Diseases, First Hospital of Jiaxing, Jiaxing, China.
  • Chen MJ; Department of Infectious Diseases, First People's Hospital of Wenling, Taizhou, China.
  • Zhang JJ; Department of Respiratory and Critical Care Medicine, Yinzhou People's Hospital, Affiliated Yinzhou Hospital, College of Medicine, Ningbo University, Ningbo, China.
  • Ju B; Department of Infectious Diseases, Taizhou Municipal Hospital, Taizhou, China.
  • Gao HN; Department of Infectious Diseases, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, No. 158 Shangtang Road, Hangzhou, 310014, Zhejiang, China.
  • Huang HJ; Department of Infectious Diseases, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, No. 158 Shangtang Road, Hangzhou, 310014, Zhejiang, China.
  • Li LJ; Department of Infectious Diseases, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, No. 158 Shangtang Road, Hangzhou, 310014, Zhejiang, China.
  • Pan HY; Department of Infectious Diseases, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, No. 158 Shangtang Road, Hangzhou, 310014, Zhejiang, China.
Sci Rep ; 11(1): 3863, 2021 02 16.
Article in English | MEDLINE | ID: covidwho-1087494
ABSTRACT
Novel coronavirus pneumonia (NCP) has been widely spread in China and several other countries. Early finding of this pneumonia from huge numbers of suspects gives clinicians a big challenge. The aim of the study was to develop a rapid screening model for early predicting NCP in a Zhejiang population, as well as its utility in other areas. A total of 880 participants who were initially suspected of NCP from January 17 to February 19 were included. Potential predictors were selected via stepwise logistic regression analysis. The model was established based on epidemiological features, clinical manifestations, white blood cell count, and pulmonary imaging changes, with the area under receiver operating characteristic (AUROC) curve of 0.920. At a cut-off value of 1.0, the model could determine NCP with a sensitivity of 85% and a specificity of 82.3%. We further developed a simplified model by combining the geographical regions and rounding the coefficients, with the AUROC of 0.909, as well as a model without epidemiological factors with the AUROC of 0.859. The study demonstrated that the screening model was a helpful and cost-effective tool for early predicting NCP and had great clinical significance given the high activity of NCP.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia / Mass Screening / SARS-CoV-2 / COVID-19 / Models, Biological Type of study: Controlled clinical trial / Diagnostic study / Prognostic study / Risk factors / Screening study Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-83054-x

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia / Mass Screening / SARS-CoV-2 / COVID-19 / Models, Biological Type of study: Controlled clinical trial / Diagnostic study / Prognostic study / Risk factors / Screening study Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-83054-x