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Clinical and Laboratory Findings in Patients With Potential Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Reinfection, May-July 2020.
Lee, James T; Hesse, Elisabeth M; Paulin, Heather N; Datta, Deblina; Katz, Lee S; Talwar, Amish; Chang, Gregory; Galang, Romeo R; Harcourt, Jennifer L; Tamin, Azaibi; Thornburg, Natalie J; Wong, Karen K; Stevens, Valerie; Kim, Kaylee; Tong, Suxiang; Zhou, Bin; Queen, Krista; Drobeniuc, Jan; Folster, Jennifer M; Sexton, D Joseph; Ramachandran, Sumathi; Browne, Hannah; Iskander, John; Mitruka, Kiren.
  • Lee JT; Health Systems Worker Safety Task Force, COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Hesse EM; Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Paulin HN; Health Systems Worker Safety Task Force, COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Datta D; Health Systems Worker Safety Task Force, COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Katz LS; Health Systems Worker Safety Task Force, COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Talwar A; Health Systems Worker Safety Task Force, COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Chang G; Health Systems Worker Safety Task Force, COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Galang RR; Health Systems Worker Safety Task Force, COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Harcourt JL; Health Systems Worker Safety Task Force, COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Tamin A; Laboratory Task Force, COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Thornburg NJ; Laboratory Task Force, COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Wong KK; Laboratory Task Force, COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Stevens V; Health Systems Worker Safety Task Force, COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Kim K; Health Systems Worker Safety Task Force, COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Tong S; Health Systems Worker Safety Task Force, COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Zhou B; Laboratory Task Force, COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Queen K; Laboratory Task Force, COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Drobeniuc J; Laboratory Task Force, COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Folster JM; Laboratory Task Force, COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Sexton DJ; Laboratory Task Force, COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Ramachandran S; Laboratory Task Force, COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Browne H; Laboratory Task Force, COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Iskander J; Laboratory Task Force, COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Mitruka K; Health Systems Worker Safety Task Force, COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Clin Infect Dis ; 73(12): 2217-2225, 2021 12 16.
Article in English | MEDLINE | ID: covidwho-1595231
ABSTRACT

BACKGROUND:

We investigated patients with potential severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection in the United States during May-July 2020.

METHODS:

We conducted case finding for patients with potential SARS-CoV-2 reinfection through the Emerging Infections Network. Cases reported were screened for laboratory and clinical findings of potential reinfection followed by requests for medical records and laboratory specimens. Available medical records were abstracted to characterize patient demographics, comorbidities, clinical course, and laboratory test results. Submitted specimens underwent further testing, including reverse transcription polymerase chain reaction (RT-PCR), viral culture, whole genome sequencing, subgenomic RNA PCR, and testing for anti-SARS-CoV-2 total antibody.

RESULTS:

Among 73 potential reinfection patients with available records, 30 patients had recurrent coronavirus disease 2019 (COVID-19) symptoms explained by alternative diagnoses with concurrent SARS-CoV-2 positive RT-PCR, 24 patients remained asymptomatic after recovery but had recurrent or persistent RT-PCR, and 19 patients had recurrent COVID-19 symptoms with concurrent SARS-CoV-2 positive RT-PCR but no alternative diagnoses. These 19 patients had symptom recurrence a median of 57 days after initial symptom onset (interquartile range 47-76). Six of these patients had paired specimens available for further testing, but none had laboratory findings confirming reinfections. Testing of an additional 3 patients with recurrent symptoms and alternative diagnoses also did not confirm reinfection.

CONCLUSIONS:

We did not confirm SARS-CoV-2 reinfection within 90 days of the initial infection based on the clinical and laboratory characteristics of cases in this investigation. Our findings support current Centers for Disease Control and Prevention (CDC) guidance around quarantine and testing for patients who have recovered from COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: Cid

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: Cid