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Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases.
Liu, Qian; Shi, Yu; Cai, Jun; Duan, Yaqi; Wang, Rongshuai; Zhang, Hongyan; Ruan, Qiurong; Li, Jiansha; Zhao, Lei; Ping, Yifang; Chen, Rong; Ren, Liang; Fei, Xiaochun; Zhang, Heng; Tang, Rui; Wang, Xi; Luo, Tao; Liu, Xindong; Huang, Xuequan; Liu, Zhenhua; Ao, Qilin; Ren, Yong; Xiong, Jing; He, Zhicheng; Wu, Haibo; Fu, Wenjuan; Zhao, Pengnan; Chen, Xinwei; Qu, Guoqiang; Wang, Yunyun; Wang, Xi; Liu, Jia; Xiang, Dongfang; Xu, Sanpeng; Zhou, Xiaowei; Li, Qingrui; Ma, Jinghong; Li, Heng; Zhang, Jie; Huang, Sizhe; Yao, Xiaohong; Zhou, Yiwu; Wang, Chaofu; Zhang, Dingyu; Wang, Guoping; Liu, Liang; Bian, Xiu-Wu.
  • Liu Q; Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
  • Shi Y; Institute of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
  • Cai J; Department of Pathology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  • Duan Y; Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
  • Wang R; Hubei Chongxin Judicial Expertise Center, Wuhan 430415, China.
  • Zhang H; Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
  • Ruan Q; Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
  • Li J; Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
  • Zhao L; Department of Pathology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  • Ping Y; Institute of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
  • Chen R; Department of Pathology, Wuhan Jinyintan Hospital, Wuhan 430023, China.
  • Ren L; Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
  • Fei X; Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  • Zhang H; Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  • Tang R; Institute of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
  • Wang X; Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
  • Luo T; Institute of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
  • Liu X; Institute of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
  • Huang X; Department of Vascular Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
  • Liu Z; Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  • Ao Q; Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
  • Ren Y; Department of Pathology, General Hospital of Central Theater Command of PLA, Wuhan 430070, China.
  • Xiong J; Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
  • He Z; Institute of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
  • Wu H; Department of Pathology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230036, China.
  • Fu W; Institute of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
  • Zhao P; Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
  • Chen X; Department of Pathology, General Hospital of Central Theater Command of PLA, Wuhan 430070, China.
  • Qu G; Hubei Chongxin Judicial Expertise Center, Wuhan 430415, China.
  • Wang Y; Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
  • Wang X; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, China.
  • Liu J; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, China.
  • Xiang D; Institute of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
  • Xu S; Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
  • Zhou X; Hubei Chongxin Judicial Expertise Center, Wuhan 430415, China.
  • Li Q; Institute of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
  • Ma J; Hubei Chongxin Judicial Expertise Center, Wuhan 430415, China.
  • Li H; Department of Pathology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230036, China.
  • Zhang J; Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
  • Huang S; Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
  • Yao X; Institute of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
  • Zhou Y; Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
  • Wang C; Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  • Zhang D; Research Center for Translational Medicine, Wuhan Jinyintan Hospital, Wuhan 430023, China.
  • Wang G; Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
  • Liu L; Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
  • Bian XW; Institute of Pathology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China.
Natl Sci Rev ; 7(12): 1868-1878, 2020 Dec.
Article in English | MEDLINE | ID: covidwho-1087785
ABSTRACT
Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics. In this study, we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents-findings that evaluated histopathological changes, immune cell signature and inflammatory factor expression in the lungs, spleen and lymph nodes. Here we show that the major pulmonary alterations included diffuse alveolar damage, interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates, macrophage infiltration and abundant production of inflammatory factors (IL-6, IP-10, TNFα and IL-1ß). The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation, including lymphopenia and macrophage accumulation. These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients.
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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Natl Sci Rev Year: 2020 Document Type: Article Affiliation country: Nsr

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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Natl Sci Rev Year: 2020 Document Type: Article Affiliation country: Nsr