Your browser doesn't support javascript.
Comparison of acute pneumonia caused by SARS-COV-2 and other respiratory viruses in children: a retrospective multi-center cohort study during COVID-19 outbreak.
Ren, Guang-Li; Wang, Xian-Feng; Xu, Jun; Li, Jun; Meng, Qiong; Xie, Guo-Qiang; Huang, Bo; Zhu, Wei-Chun; Lin, Jing; Tang, Cheng-He; Ye, Sheng; Li, Zhuo; Zhu, Jie; Tang, Zhen; Ma, Ming-Xin; Xie, Cong; Wu, Ying-Wen; Liu, Chen-Xi; Yang, Fang; Zhou, Yu-Zong; Zheng, Ying; Lan, Shu-Ling; Chen, Jian-Feng; Ye, Feng; He, Yu; Wu, Ben-Qing; Chen, Long; Fu, Si-Mao; Zheng, Cheng-Zhong; Shi, Yuan.
  • Ren GL; Department of Pediatrics, General Hospital of Southern Theater Command of PLA, 111 Liuhua Road, Yuexiu District, Guangzhou, 510010, Guangdong, China. guangliren@hotmail.com.
  • Wang XF; Department of Pediatrics, the Third People's Hospital of Shenzhen, Shenzhen, 518100, Guangdong, China.
  • Xu J; Pediatric Intensive Care Unit, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430010, China.
  • Li J; Pediatric Intensive Care Unit, Maternal and Child Health Hospital of Huangshi, Huangshi, 435000, Hubei, China.
  • Meng Q; Department of Pediatrics, the Second People's Hospital of Guangdong Province, Guangzhou, 510317, China.
  • Xie GQ; Department of Pediatrics, General Hospital of Southern Theater Command of PLA, 111 Liuhua Road, Yuexiu District, Guangzhou, 510010, Guangdong, China.
  • Huang B; Department of Pediatrics, the Third Affiliated Hospital of Zunyi Medical University (the First People's Hospital of Zunyi), Guizhou, 563000, China.
  • Zhu WC; Department of Pediatrics, the Eighth People's Hospital of Guangzhou, Guangzhou, 510440, China.
  • Lin J; Department of Pediatrics, the Eighth People's Hospital of Guangzhou, Guangzhou, 510440, China.
  • Tang CH; Department of Pediatrics, the First Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453100, Henan, China.
  • Ye S; Pediatric Intensive Care Unit, the Children's Hospital Zhejiang University School of Medicine, Hangzhou, 310000, China.
  • Li Z; Department of Emergency / Critical Medicine, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China.
  • Zhu J; Department of Pediatrics, General Hospital of Southern Theater Command of PLA, 111 Liuhua Road, Yuexiu District, Guangzhou, 510010, Guangdong, China.
  • Tang Z; Department of Pediatrics, General Hospital of Southern Theater Command of PLA, 111 Liuhua Road, Yuexiu District, Guangzhou, 510010, Guangdong, China.
  • Ma MX; Department of Pediatrics, General Hospital of Southern Theater Command of PLA, 111 Liuhua Road, Yuexiu District, Guangzhou, 510010, Guangdong, China.
  • Xie C; Department of Pediatrics, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.
  • Wu YW; Department of Medical information date room, General Hospital of Southern Theater Command of PLA, Guangzhou, 510010, China.
  • Liu CX; Department of Medical information date room, General Hospital of Southern Theater Command of PLA, Guangzhou, 510010, China.
  • Yang F; Department of Pediatrics, the First Affiliated Hospital of Jinan University, Guangzhou, 510632, China.
  • Zhou YZ; Department of Pediatrics, Maternal and Child Health Hospital of Yangjiang, Yangjiang, 529500, Guangdong, China.
  • Zheng Y; Department of Pediatrics, Shenzhen Hospital Affiliated to the University of Chinese Academy of Sciences, Shenzhen, 518107, Guangdong, China.
  • Lan SL; Department of Pediatrics, Nanfang Hospital of Southern Medical University, Guangzhou, 510515, China.
  • Chen JF; Department of Pediatrics, Zhujiang Hospital of Southern Medical University, Guangzhou, 510280, China.
  • Ye F; Department of Pediatrics, Military Hospital of 74 Group of PLA, Guangzhou, 510318, China.
  • He Y; Department of Neonatology, Children's Hospital of Chongqing Medical University/Ministry of Education Key Laboratory of Child/Development and Disorders/National Clinical Research Center for Child Health and Disorders/Chongqing Key Laboratory of Pediatrics, Chongqing, 400014, China.
  • Wu BQ; Department of Pediatrics, Shenzhen Hospital Affiliated to the University of Chinese Academy of Sciences, Shenzhen, 518107, Guangdong, China.
  • Chen L; Department of Neonatology, Children's Hospital of Chongqing Medical University/Ministry of Education Key Laboratory of Child/Development and Disorders/National Clinical Research Center for Child Health and Disorders/Chongqing Key Laboratory of Pediatrics, Chongqing, 400014, China.
  • Fu SM; Department of Pediatrics, Zhongshan Boai Hospital, Zhongshan, 528403, Guangdong, China. zs5319753@163.com.
  • Zheng CZ; Department of Pediatrics, Strategic Support Force Medical Center of PLA, Beijing, 100101, China. zcz3066@126.com.
  • Shi Y; Department of Neonatology, Children's Hospital of Chongqing Medical University/Ministry of Education Key Laboratory of Child/Development and Disorders/National Clinical Research Center for Child Health and Disorders/Chongqing Key Laboratory of Pediatrics, Chongqing, 400014, China. petshi530@vip.163.
Mil Med Res ; 8(1): 13, 2021 02 16.
Article in English | MEDLINE | ID: covidwho-1088620
ABSTRACT

BACKGROUND:

Until January 18, 2021, coronavirus disease-2019 (COVID-19) has infected more than 93 million individuals and has caused a certain degree of panic. Viral pneumonia caused by common viruses such as respiratory syncytial virus, rhinovirus, human metapneumovirus, human bocavirus, and parainfluenza viruses have been more common in children. However, the incidence of COVID-19 in children was significantly lower than that in adults. The purpose of this study was to describe the clinical manifestations, treatment and outcomes of COVID-19 in children compared with those of other sources of viral pneumonia diagnosed during the COVID-19 outbreak.

METHODS:

Children with COVID-19 and viral pneumonia admitted to 20 hospitals were enrolled in this retrospective multi-center cohort study. A total of 64 children with COVID-19 were defined as the COVID-19 cohort, of which 40 children who developed pneumonia were defined as the COVID-19 pneumonia cohort. Another 284 children with pneumonia caused by other viruses were defined as the viral pneumonia cohort. The epidemiologic, clinical, and laboratory findings were compared by Kolmogorov-Smirnov test, t-test, Mann-Whitney U test and Contingency table method. Drug usage, immunotherapy, blood transfusion, and need for oxygen support were collected as the treatment indexes. Mortality, intensive care needs and symptomatic duration were collected as the outcome indicators.

RESULTS:

Compared with the viral pneumonia cohort, children in the COVID-19 cohort were mostly exposed to family members confirmed to have COVID-19 (53/64 vs. 23/284), were of older median age (6.3 vs. 3.2 years), and had a higher proportion of ground-glass opacity (GGO) on computed tomography (18/40 vs. 0/38, P < 0.001). Children in the COVID-19 pneumonia cohort had a lower proportion of severe cases (1/40 vs. 38/284, P = 0.048), and lower cases with high fever (3/40 vs. 167/284, P < 0.001), requiring intensive care (1/40 vs. 32/284, P < 0.047) and with shorter symptomatic duration (median 5 vs. 8 d, P < 0.001). The proportion of cases with evaluated inflammatory indicators, biochemical indicators related to organ or tissue damage, D-dimer and secondary bacterial infection were lower in the COVID-19 pneumonia cohort than those in the viral pneumonia cohort (P < 0.05). No statistical differences were found in the duration of positive PCR results from pharyngeal swabs in 25 children with COVID-19 who received antiviral drugs (lopinavir-ritonavir, ribavirin, and arbidol) as compared with duration in 39 children without antiviral therapy [median 10 vs. 9 d, P = 0.885].

CONCLUSION:

The symptoms and severity of COVID-19 pneumonia in children were no more severe than those in children with other viral pneumonia. Lopinavir-ritonavir, ribavirin and arbidol do not shorten the duration of positive PCR results from pharyngeal swabs in children with COVID-19. During the COVID-19 outbreak, attention also must be given to children with infection by other pathogens infection.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Severe Acute Respiratory Syndrome / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Country/Region as subject: Asia Language: English Journal: Mil Med Res Year: 2021 Document Type: Article Affiliation country: S40779-021-00306-7

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Severe Acute Respiratory Syndrome / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Country/Region as subject: Asia Language: English Journal: Mil Med Res Year: 2021 Document Type: Article Affiliation country: S40779-021-00306-7