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Perspective: Vitamin D supplementation prevents rickets and acute respiratory infections when given as daily maintenance but not as intermittent bolus: implications for COVID-19.
Griffin, George; Hewison, Martin; Hopkin, Julian; Kenny, Rose Anne; Quinton, Richard; Rhodes, Jonathan; Subramanian, Sreedhar; Thickett, David.
  • Griffin G; St George's, University of London, London, UK.
  • Hewison M; University of Birmingham, Birmingham, UK.
  • Hopkin J; Swansea University, Swansea, UK.
  • Kenny RA; Trinity College Dublin, Dublin, Ireland.
  • Quinton R; Newcastle University, Newcastle upon Tyne, UK.
  • Rhodes J; University of Liverpool, Liverpool, UK rhodesjm@liverpool.ac.uk.
  • Subramanian S; Royal Liverpool University Hospital, Liverpool, UK.
  • Thickett D; University of Birmingham, Birmingham, UK.
Clin Med (Lond) ; 21(2): e144-e149, 2021 Mar.
Article in English | MEDLINE | ID: covidwho-1089178
Semantic information from SemMedBD (by NLM)
1. Vitamin supplementation PREVENTS Rickets
Subject
Vitamin supplementation
Predicate
PREVENTS
Object
Rickets
2. Vitamin supplementation PREVENTS Acute respiratory infections
Subject
Vitamin supplementation
Predicate
PREVENTS
Object
Acute respiratory infections
3. Vitamin D Deficiency CAUSES Disease
Subject
Vitamin D Deficiency
Predicate
CAUSES
Object
Disease
4. Vitamin supplementation TREATS Tuberculosis
Subject
Vitamin supplementation
Predicate
TREATS
Object
Tuberculosis
5. Vitamin supplementation PREVENTS Rickets
Subject
Vitamin supplementation
Predicate
PREVENTS
Object
Rickets
6. Vitamin supplementation PREVENTS Acute respiratory infections
Subject
Vitamin supplementation
Predicate
PREVENTS
Object
Acute respiratory infections
7. Vitamin D Deficiency CAUSES Disease
Subject
Vitamin D Deficiency
Predicate
CAUSES
Object
Disease
8. Vitamin supplementation TREATS Tuberculosis
Subject
Vitamin supplementation
Predicate
TREATS
Object
Tuberculosis
ABSTRACT
The value of vitamin D supplementation in the treatment or prevention of various conditions is often viewed with scepticism as a result of contradictory results of randomised trials. It is now becoming apparent that there is a pattern to these inconsistencies. A recent large trial has shown that high-dose intermittent bolus vitamin D therapy is ineffective at preventing rickets - the condition that is most unequivocally caused by vitamin D deficiency. There is a plausible biological explanation since high-dose bolus replacement induces long-term expression of the catabolic enzyme 24-hydroxylase and fibroblast growth factor 23, both of which have vitamin D inactivating effects. Meta-analyses of vitamin D supplementation in prevention of acute respiratory infection and trials in tuberculosis and other conditions also support efficacy of low dose daily maintenance rather than intermittent bolus dosing. This is particularly relevant during the current COVID-19 pandemic given the well-documented associations between COVID-19 risk and vitamin D deficiency. We would urge that clinicians take note of these findings and give strong support to widespread use of daily vitamin D supplementation.
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Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Tract Infections / Rickets / Vitamin D / Vitamin D Deficiency / Dietary Supplements / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews Topics: Traditional medicine Limits: Humans Language: English Journal: Clin Med (Lond) Year: 2021 Document Type: Article Affiliation country: Clinmed.2021-0035

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Tract Infections / Rickets / Vitamin D / Vitamin D Deficiency / Dietary Supplements / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews Topics: Traditional medicine Limits: Humans Language: English Journal: Clin Med (Lond) Year: 2021 Document Type: Article Affiliation country: Clinmed.2021-0035