Convalescent plasma therapy prevents acute respiratory distress syndrome in patients with sars-cov-2 virus disease
Revista Cubana de Hematologia, Inmunologia y Hemoterapia
; 36(special issue):1-16, 2020.
Article
in English
| Scopus | ID: covidwho-1089706
ABSTRACT
Background:
SARS-CoV-2 disease 2019 is a pandemic with no specific therapeutic agents and substantial mortality. The success of convalescent plasma therapy is based on the transfused plasma had high concentrations of anti-SARS-CoV-2 antibodies, and on the safe preparation of serum to eliminate potential risk factors, such as the transmission of viruses via transfusion.Methods:
Five patients laboratory confirmed COVID-19, diagnosed using reverse transcriptase–polymerase chain reaction (RT-PCR) classified like of care and seriously non-ventilated patients with moderate hypoxemia were received 300 mL convalescent plasma treatment. Each donation was tested for antibody titers IgG class anti-SARS-CoV-2 by UMELISA. The transfused plasma units had an average antibody titer of 836.00 ± 617.155. The time interval between the onset of symptoms and transfusion was 9 days (7.20± 3). Before and after each transfusion, clinical and laboratory parameters were evaluated.Results:
At 24-hour after the plasma transfusion, oxygen partial pressure increased from medium value of 70.4 to 101.6 mm Hg, C-reactive protein and lactate dehydrogenase enzyme values decreased in 3 of 5 patients;however, the ferritin values increased in all the patients. Post-transfusion hospital discharge time was from 48 hours to 12 days and the SARS-CoV-2 PCR was negative between 3 and 5 days. No adverse transfusion reactions were reported.Conclusion:
This report emphasis about the efficacy and security of convalescent plasma transfusion to care and seriously non-ventilated patients infected like a preventive therapy for severe respiratory distress for SARS-CoV-2 virus disease. © 2020, Editorial Ciencias Medicas. All rights reserved.
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Collection:
Databases of international organizations
Database:
Scopus
Language:
English
Journal:
Revista Cubana de Hematologia, Inmunologia y Hemoterapia
Year:
2020
Document Type:
Article
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