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Preferences of inflammatory arthritis patients for biological disease-modifying antirheumatic drugs in the first 100 days of the COVID-19 pandemic
Kalyoncu, Umut; Pehlivan, Yavuz; Akar, Servet; Kasifoglu, Timuçin; Kimyon, Gezmis; Karadag, Ömer; Dalkiliç, Hüseyin Ediz; Ertenli, Ali Ihsan; Kiliç, Levent; Ersözlü, Duygu; Bes, Cemal; Emmungil, Hakan; Mercan, Ridvan; Ediboglu, Elif Durak; Kanitez, Nilüfer; Bilgin, Emre; Çolak, Seda; Koca, Süleyman Serdar; Gönüllü, Emel; Küçüksahin, Orhan; Coskun, Nihan; Yagiz, Burcu; Kiraz, Sedat.
  • Kalyoncu U; Department of Internal Medicine, Division of Rheumatology, Hacettepe University, Faculty of Medicine, Ankara, Turkey
  • Pehlivan Y; Department of Internal Medicine, Division of Rheumatology, Uludag University, Faculty of Medicine, Bursa, Turkey
  • Akar S; Department of Internal Medicine, Division of Rheumatology, Izmir Katip Çelebi University, Faculty of Medicine, Izmir, Turkey
  • Kasifoglu T; Department of Internal Medicine, Division of Rheumatology, Eskisehir Osmangazi University, Faculty of Medicine, Eskisehir, Turkey
  • Kimyon G; Department of Internal Medicine, Division of Rheumatology, Faculty of Medicine, Hatay Mustafa Kemal University, Hatay, Turkey
  • Karadag Ö; Department of Internal Medicine, Division of Rheumatology, Hacettepe University, Faculty of Medicine, Ankara, Turkey
  • Dalkiliç HE; Department of Internal Medicine, Division of Rheumatology, Uludag University, Faculty of Medicine, Bursa, Turkey
  • Ertenli AI; Department of Internal Medicine, Division of Rheumatology, Hacettepe University, Faculty of Medicine, Ankara, Turkey
  • Kiliç L; Department of Internal Medicine, Division of Rheumatology, Hacettepe University, Faculty of Medicine, Ankara, Turkey
  • Ersözlü D; Department of Internal Medicine, Division of Rheumatology, Ministry of Health Adana City Training and Research Hospital, Adana, Turkey
  • Bes C; Department of Internal Medicine, Division of Rheumatology, Basaksehir Çam and Sakura City Hospital, Istanbul, Turkey
  • Emmungil H; Department of Internal Medicine, Division of Rheumatology, Faculty of Medicine, Trakya University, Edirne, Turkey
  • Mercan R; Department of Internal Medicine, Division of Rheumatology, Faculty of Medicine, Tekirdag Namik Kemal University, Tekirdag, Turkey
  • Ediboglu ED; Department of Internal Medicine, Division of Rheumatology, Izmir Katip Çelebi University, Faculty of Medicine, Izmir, Turkey
  • Kanitez N; Department of Internal Medicine, Division of Rheumatology, Faculty of Medicine, Koç University, Istanbul, Turkey
  • Bilgin E; Department of Internal Medicine, Division of Rheumatology, Hacettepe University, Faculty of Medicine, Ankara, Turkey
  • Çolak S; Department of Internal Medicine, Division of Rheumatology, Gulhane Faculty of Medicine, University of Health Sciences, Ankara, Turkey
  • Koca SS; Department of Internal Medicine, Division of Rheumatology, Faculty of Medicine, Firat University, Elazig, Turkey
  • Gönüllü E; Department of Internal Medicine, Division of Rheumatology, Faculty of Medicine, Sakarya University, Sakarya, Turkey
  • Küçüksahin O; Department of Internal Medicine, Division of Rheumatology, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey
  • Coskun N; Department of Internal Medicine, Division of Rheumatology, Uludag University, Faculty of Medicine, Bursa, Turkey
  • Yagiz B; Department of Internal Medicine, Division of Rheumatology, Uludag University, Faculty of Medicine, Bursa, Turkey
  • Kiraz S; Department of Internal Medicine, Division of Rheumatology, Hacettepe University, Faculty of Medicine, Ankara, Turkey
Turk J Med Sci ; 51(4): 1615-1623, 2021 08 30.
Article in English | MEDLINE | ID: covidwho-1090270
ABSTRACT
Background/

aim:

To evaluate treatment adherence and predictors of drug discontinuation among patients with inflammatory arthritis receiving bDMARDs within the first 100 days after the announcement of the COVID-19 pandemic. Materials and

methods:

A total of 1871 patients recorded in TReasure registry for whom advanced therapy was prescribed for rheumatoid arthritis (RA) or spondyloarthritis (SpA) within the 3 months (6­9 months for rituximab) before the declaration of COVID-19 pandemic were evaluated, and 1394 (74.5%) responded to the phone survey. Patients' data regarding demographic, clinical characteristics and disease activity before the pandemic were recorded. The patients were inquired about the diagnosis of COVID-19, the rate of continuation on bDMARDs, the reasons for treatment discontinuation, if any, and the current general disease activity (visual analog scale, [VAS]).

Results:

A total of 1394 patients (493 RA [47.3% on anti-TNF] patients and 901 SpA [90.0% on anti-TNF] patients) were included in the study. Overall, 2.8% of the patients had symptoms suggesting COVID-19, and 2 (0.15%) patients had PCR-confirmed COVID-19. Overall, 18.1% of all patients (13.8% of the RA and 20.5% of the SpA; p = 0.003) discontinued their bDMARDs. In the SpA group, the patients who discontinued bDMARDs were younger (40 [21­73] vs. 44 years [20­79]; p = 0.005) and had higher general disease activity; however, no difference was relevant for RA patients.

Conclusion:

Although the COVID-19 was quite uncommon in the first 100 days of the pandemic, nearly one-fifth of the patients discontinued bDMARDs within this period. The long-term effects of the pandemic should be monitored.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Arthritis, Rheumatoid / Antirheumatic Agents / Medication Adherence / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Turk J Med Sci Year: 2021 Document Type: Article Affiliation country: Sag-2012-5

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Arthritis, Rheumatoid / Antirheumatic Agents / Medication Adherence / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Turk J Med Sci Year: 2021 Document Type: Article Affiliation country: Sag-2012-5