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Cross-sectional observational study of epidemiology of COVID-19 and clinical outcomes of hospitalised patients in North West London during March and April 2020.
Gopal Rao, Guduru; Allen, Alexander; Papineni, Padmasayee; Wang, Liyang; Anderson, Charlotte; McGregor, Alastair; Whittington, Ashley; John, Laurence; Harris, Miriam; Hiles, Stephen; Nicholas, Thomas; Adams, Katherine; Akbar, Ayesha; Blomquist, Paula; Decraene, Valerie; Patel, Bharat; Manuel, Rohini; Chow, Yimmy; Kuper, Martin.
  • Gopal Rao G; Departments of Microbiology, Infectious Diseases, Emergency, Research and Development and Corporate Affairs, London North West University Healthcare NHS Trust, London, UK ggopalrao@nhs.net.
  • Allen A; Field Epidemiology and Health Protection Units, Public Health England, London, UK.
  • Papineni P; Departments of Microbiology, Infectious Diseases, Emergency, Research and Development and Corporate Affairs, London North West University Healthcare NHS Trust, London, UK.
  • Wang L; Departments of Microbiology, Infectious Diseases, Emergency, Research and Development and Corporate Affairs, London North West University Healthcare NHS Trust, London, UK.
  • Anderson C; Field Epidemiology and Health Protection Units, Public Health England, London, UK.
  • McGregor A; Departments of Microbiology, Infectious Diseases, Emergency, Research and Development and Corporate Affairs, London North West University Healthcare NHS Trust, London, UK.
  • Whittington A; Departments of Microbiology, Infectious Diseases, Emergency, Research and Development and Corporate Affairs, London North West University Healthcare NHS Trust, London, UK.
  • John L; Departments of Microbiology, Infectious Diseases, Emergency, Research and Development and Corporate Affairs, London North West University Healthcare NHS Trust, London, UK.
  • Harris M; Departments of Microbiology, Infectious Diseases, Emergency, Research and Development and Corporate Affairs, London North West University Healthcare NHS Trust, London, UK.
  • Hiles S; Departments of Microbiology, Infectious Diseases, Emergency, Research and Development and Corporate Affairs, London North West University Healthcare NHS Trust, London, UK.
  • Nicholas T; Departments of Microbiology, Infectious Diseases, Emergency, Research and Development and Corporate Affairs, London North West University Healthcare NHS Trust, London, UK.
  • Adams K; Departments of Microbiology, Infectious Diseases, Emergency, Research and Development and Corporate Affairs, London North West University Healthcare NHS Trust, London, UK.
  • Akbar A; Departments of Microbiology, Infectious Diseases, Emergency, Research and Development and Corporate Affairs, London North West University Healthcare NHS Trust, London, UK.
  • Blomquist P; Field Epidemiology and Health Protection Units, Public Health England, London, UK.
  • Decraene V; Field Epidemiology and Health Protection Units, Public Health England, London, UK.
  • Patel B; Field Epidemiology and Health Protection Units, Public Health England, London, UK.
  • Manuel R; Field Epidemiology and Health Protection Units, Public Health England, London, UK.
  • Chow Y; Field Epidemiology and Health Protection Units, Public Health England, London, UK.
  • Kuper M; Departments of Microbiology, Infectious Diseases, Emergency, Research and Development and Corporate Affairs, London North West University Healthcare NHS Trust, London, UK.
BMJ Open ; 11(2): e044384, 2021 02 18.
Article in English | MEDLINE | ID: covidwho-1090929
ABSTRACT

OBJECTIVE:

The aim of this paper is to describe evolution, epidemiology and clinical outcomes of COVID-19 in subjects tested at or admitted to hospitals in North West London.

DESIGN:

Observational cohort study.

SETTING:

London North West Healthcare NHS Trust (LNWH).

PARTICIPANTS:

Patients tested and/or admitted for COVID-19 at LNWH during March and April 2020 MAIN OUTCOME

MEASURES:

Descriptive and analytical epidemiology of demographic and clinical outcomes (intensive care unit (ICU) admission, mechanical ventilation and mortality) of those who tested positive for COVID-19.

RESULTS:

The outbreak began in the first week of March 2020 and reached a peak by the end of March and first week of April. In the study period, 6183 tests were performed in on 4981 people. Of the 2086 laboratory confirmed COVID-19 cases, 1901 were admitted to hospital. Older age group, men and those of black or Asian minority ethnic (BAME) group were predominantly affected (p<0.05). These groups also had more severe infection resulting in ICU admission and need for mechanical ventilation (p<0.05). However, in a multivariate analysis, only increasing age was independently associated with increased risk of death (p<0.05). Mortality rate was 26.9% in hospitalised patients.

CONCLUSION:

The findings confirm that men, BAME and older population were most commonly and severely affected groups. Only older age was independently associated with mortality.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Hospitalization Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Country/Region as subject: Europa Language: English Journal: BMJ Open Year: 2021 Document Type: Article Affiliation country: Bmjopen-2020-044384

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Hospitalization Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Country/Region as subject: Europa Language: English Journal: BMJ Open Year: 2021 Document Type: Article Affiliation country: Bmjopen-2020-044384