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Do Corticosteroid Injections for the Treatment of Pain Influence the Efficacy of mRNA COVID-19 Vaccines?
Lee, Haewon; Punt, Jennifer A; Miller, David C; Nagpal, Ameet; Smith, Clark C; Sayeed, Yusef; Patel, Jaymin; Stojanovic, Milan P; Popescu, Adrian; McCormick, Zachary L.
  • Lee H; University of California, San Diego, Department of Orthopedic Surgery, San Diego, California, USA.
  • Punt JA; University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, USA.
  • Miller DC; Napa Pain Institute, Napa, California, USA.
  • Nagpal A; Department of Anesthesiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
  • Smith CC; Columbia University Medical Center, Rehabilitation and Regenerative Medicine, New York, New York, USA.
  • Sayeed Y; Uniformed Services University of the Health Sciences, Department of Physical Medicine and Rehabilitation, Department of Family Medicine, Eglin AFB, Florida, USA.
  • Patel J; Emory University, Department of Orthopedics, Atlanta, Georgia, USA.
  • Stojanovic MP; Anesthesiology, Critical Care and Pain Medicine Service, VA Boston Healthcare System, Harvard Medical School, Boston, Massachusetts, USA.
  • Popescu A; Hospital of University of Pennsylvania, Department of Physical Medicine and Rehabilitation, Philadelphia, Pennsylvania, USA.
  • McCormick ZL; University of Utah, Division of Physical Medicine and Rehabilitation, Salt Lake City, Utah, USA.
Pain Med ; 22(4): 994-1000, 2021 04 20.
Article in English | MEDLINE | ID: covidwho-1091224
ABSTRACT
MYTH Corticosteroid injection for the treatment of pain and inflammation is known to decrease the efficacy of the messenger ribonucleic acid (mRNA) vaccines for coronavirus disease 2019 (COVID-19). FACT There is currently no direct evidence to suggest that a corticosteroid injection before or after the administration of an mRNA COVID-19 vaccine decreases the efficacy of the vaccine.However, based on the known timeline of hypothalamic-pituitary-adrenal (HPA) axis suppression following epidural and intraarticular corticosteroid injections, and the timeline of the reported peak efficacy of the Pfizer-BioNTech and Moderna vaccines, physicians should consider timing an elective corticosteroid injection such that it is administered no less than 2 weeks prior to a COVID-19 mRNA vaccine dose and no less than 1 week following a COVID-19 mRNA vaccine dose, whenever possible.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pain / Vaccines, Synthetic / Adrenal Cortex Hormones / COVID-19 Vaccines / COVID-19 Type of study: Experimental Studies Topics: Vaccines Limits: Humans Language: English Journal: Pain Med Journal subject: Neurology / Psychophysiology Year: 2021 Document Type: Article Affiliation country: Pm

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pain / Vaccines, Synthetic / Adrenal Cortex Hormones / COVID-19 Vaccines / COVID-19 Type of study: Experimental Studies Topics: Vaccines Limits: Humans Language: English Journal: Pain Med Journal subject: Neurology / Psychophysiology Year: 2021 Document Type: Article Affiliation country: Pm