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Temporal association between human upper respiratory and gut bacterial microbiomes during the course of COVID-19 in adults.
Xu, Rong; Lu, Renfei; Zhang, Tao; Wu, Qunfu; Cai, Weihua; Han, Xudong; Wan, Zhenzhou; Jin, Xia; Zhang, Zhigang; Zhang, Chiyu.
  • Xu R; Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
  • Lu R; Pathogen Discovery and Evolution Unit, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
  • Zhang T; Clinical Laboratory, Nantong Third Hospital Affiliated to Nantong University, Nantong, China.
  • Wu Q; State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Life Sciences, Yunnan University, Kunming, Yunnan, China.
  • Cai W; State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Life Sciences, Yunnan University, Kunming, Yunnan, China.
  • Han X; Clinical Laboratory, Nantong Third Hospital Affiliated to Nantong University, Nantong, China.
  • Wan Z; Clinical Laboratory, Nantong Third Hospital Affiliated to Nantong University, Nantong, China.
  • Jin X; Medical Laboratory of Taizhou Fourth People's Hospital, Taizhou, China.
  • Zhang Z; Shanghai Public Health Clinical Center, Fudan University, Shanghai, China. jinxia@shphc.org.cn.
  • Zhang C; State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Life Sciences, Yunnan University, Kunming, Yunnan, China. zhangzhigang@ynu.edu.cn.
Commun Biol ; 4(1): 240, 2021 02 18.
Article in English | MEDLINE | ID: covidwho-1091448
ABSTRACT
SARS-CoV-2 is the cause of COVID-19. It infects multiple organs including the respiratory tract and gut. Dynamic changes of regional microbiomes in infected adults are largely unknown. Here, we performed longitudinal analyses of throat and anal swabs from 35 COVID-19 and 19 healthy adult controls, as well as 10 non-COVID-19 patients with other diseases, by 16 S rRNA gene sequencing. The results showed a partitioning of the patients into 3-4 categories based on microbial community types (I-IV) in both sites. The bacterial diversity was lower in COVID-19 patients than healthy controls and decreased gradually from community type I to III/IV. Although the dynamic change of microbiome was complex during COVID-19, a synchronous restoration of both the upper respiratory and gut microbiomes from early dysbiosis towards late more diverse status was observed in 6/8 mild COVID-19 adult patients. These findings reveal previously unknown interactions between upper respiratory and gut microbiomes during COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory System / Microbiota / Gastrointestinal Microbiome / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Commun Biol Year: 2021 Document Type: Article Affiliation country: S42003-021-01796-w

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory System / Microbiota / Gastrointestinal Microbiome / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Commun Biol Year: 2021 Document Type: Article Affiliation country: S42003-021-01796-w