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COVID-19-from mucosal immunology to IBD patients.
Weidinger, Carl; Hegazy, Ahmed Nabil; Glauben, Rainer; Siegmund, Britta.
  • Weidinger C; Department for Medicine (Gastroenterology, Infectious diseases, Rheumatology), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Campus Benjamin Franklin, Berlin, Germany.
  • Hegazy AN; Clinician Scientist Program, Berlin Institute of Health, Berlin, Germany.
  • Glauben R; Department for Medicine (Gastroenterology, Infectious diseases, Rheumatology), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Campus Benjamin Franklin, Berlin, Germany.
  • Siegmund B; Clinician Scientist Program, Berlin Institute of Health, Berlin, Germany.
Mucosal Immunol ; 14(3): 566-573, 2021 05.
Article in English | MEDLINE | ID: covidwho-1091501
Semantic information from SemMedBD (by NLM)
1. Inflammatory Bowel Diseases PROCESS_OF Patients
Subject
Inflammatory Bowel Diseases
Predicate
PROCESS_OF
Object
Patients
2. Epithelial Cells PART_OF Intestines
Subject
Epithelial Cells
Predicate
PART_OF
Object
Intestines
3. 2019 novel coronavirus CAUSES Disease
Subject
2019 novel coronavirus
Predicate
CAUSES
Object
Disease
4. Pneumonia NEG_COEXISTS_WITH Disease
Subject
Pneumonia
Predicate
NEG_COEXISTS_WITH
Object
Disease
5. Systemic inflammatory response NEG_COEXISTS_WITH Disease
Subject
Systemic inflammatory response
Predicate
NEG_COEXISTS_WITH
Object
Disease
6. Tropism PROCESS_OF Intestines
Subject
Tropism
Predicate
PROCESS_OF
Object
Intestines
7. Infected PROCESS_OF Persons
Subject
Infected
Predicate
PROCESS_OF
Object
Persons
8. Therapeutic immunosuppression AFFECTS Patients
Subject
Therapeutic immunosuppression
Predicate
AFFECTS
Object
Patients
9. Mucous Membrane LOCATION_OF IMPACT gene
Subject
Mucous Membrane
Predicate
LOCATION_OF
Object
IMPACT gene
10. IMPACT gene PART_OF Persons
Subject
IMPACT gene
Predicate
PART_OF
Object
Persons
11. Inflammatory Bowel Diseases PROCESS_OF Patients
Subject
Inflammatory Bowel Diseases
Predicate
PROCESS_OF
Object
Patients
12. Epithelial Cells PART_OF Intestines
Subject
Epithelial Cells
Predicate
PART_OF
Object
Intestines
13. 2019 novel coronavirus CAUSES Disease
Subject
2019 novel coronavirus
Predicate
CAUSES
Object
Disease
14. Pneumonia NEG_COEXISTS_WITH Disease
Subject
Pneumonia
Predicate
NEG_COEXISTS_WITH
Object
Disease
15. Systemic inflammatory response NEG_COEXISTS_WITH Disease
Subject
Systemic inflammatory response
Predicate
NEG_COEXISTS_WITH
Object
Disease
16. Tropism PROCESS_OF Intestines
Subject
Tropism
Predicate
PROCESS_OF
Object
Intestines
17. Infected PROCESS_OF Persons
Subject
Infected
Predicate
PROCESS_OF
Object
Persons
18. Therapeutic immunosuppression AFFECTS Patients
Subject
Therapeutic immunosuppression
Predicate
AFFECTS
Object
Patients
19. Mucous Membrane LOCATION_OF IMPACT gene
Subject
Mucous Membrane
Predicate
LOCATION_OF
Object
IMPACT gene
20. IMPACT gene PART_OF Persons
Subject
IMPACT gene
Predicate
PART_OF
Object
Persons
ABSTRACT
Viral infections with SARS-CoV-2 can cause a multi-facetted disease, which is not only characterized by pneumonia and overwhelming systemic inflammatory immune responses, but which can also directly affect the digestive system and infect intestinal epithelial cells. Here, we review the current understanding of intestinal tropism of SARS-CoV-2 infection, its impact on mucosal function and immunology and summarize the effect of immune-suppression in patients with inflammatory bowel disease (IBD) on disease outcome of COVID-19 and discuss IBD-relevant implications for the clinical management of SARS-CoV-2 infected individuals.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Inflammatory Bowel Diseases / Immunity, Mucosal / Host-Pathogen Interactions / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study Topics: Long Covid Limits: Humans Language: English Journal: Mucosal Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: S41385-021-00384-9

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Inflammatory Bowel Diseases / Immunity, Mucosal / Host-Pathogen Interactions / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study Topics: Long Covid Limits: Humans Language: English Journal: Mucosal Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: S41385-021-00384-9