Open Science Resources for the Mass Spectrometry-Based Analysis of SARS-CoV-2.
J Proteome Res
; 20(3): 1464-1475, 2021 03 05.
Article
in English
| MEDLINE | ID: covidwho-1091530
ABSTRACT
The SARS-CoV-2 virus is the causative agent of the 2020 pandemic leading to the COVID-19 respiratory disease. With many scientific and humanitarian efforts ongoing to develop diagnostic tests, vaccines, and treatments for COVID-19, and to prevent the spread of SARS-CoV-2, mass spectrometry research, including proteomics, is playing a role in determining the biology of this viral infection. Proteomics studies are starting to lead to an understanding of the roles of viral and host proteins during SARS-CoV-2 infection, their protein-protein interactions, and post-translational modifications. This is beginning to provide insights into potential therapeutic targets or diagnostic strategies that can be used to reduce the long-term burden of the pandemic. However, the extraordinary situation caused by the global pandemic is also highlighting the need to improve mass spectrometry data and workflow sharing. We therefore describe freely available data and computational resources that can facilitate and assist the mass spectrometry-based analysis of SARS-CoV-2. We exemplify this by reanalyzing a virus-host interactome data set to detect protein-protein interactions and identify host proteins that could potentially be used as targets for drug repurposing.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Mass Spectrometry
/
Information Dissemination
/
SARS-CoV-2
/
COVID-19
Type of study:
Diagnostic study
/
Observational study
Topics:
Vaccines
Limits:
Humans
Language:
English
Journal:
J Proteome Res
Journal subject:
Biochemistry
Year:
2021
Document Type:
Article
Affiliation country:
Acs.jproteome.0c00929
Similar
MEDLINE
...
LILACS
LIS