Cyclin-dependent Kinases as Emerging Targets for Developing Novel Antiviral Therapeutics.
Trends Microbiol
; 29(9): 836-848, 2021 09.
Article
in English
| MEDLINE | ID: covidwho-1091623
ABSTRACT
Besides its prominent role in cell proliferation, cyclin-dependent kinases (CDKs) are key players in viral infections as both DNA and RNA viruses modify CDK function to favor viral replication. Recently, a number of specific pharmacological CDK inhibitors have been developed and approved for cancer treatment. The repurposing of these specific CDK inhibitors for the treatment of viral infections may represent a novel effective therapeutic strategy to combat old and emergent viruses. In this review, we describe the role, mechanisms of action, and potential of CDKs as antiviral drug targets. We also discuss the current clinical state of novel specific CDK inhibitors, focusing on their putative use as antivirals, especially against new emerging viruses.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Virus Diseases
/
Cyclin-Dependent Kinases
/
SARS-CoV-2
/
COVID-19 Drug Treatment
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Trends Microbiol
Journal subject:
Microbiology
Year:
2021
Document Type:
Article
Affiliation country:
J.tim.2021.01.014
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