A systematic review of clinical and laboratory parameters associated with increased severity among COVID-19 patients.
Diabetes Metab Syndr
; 15(2): 535-541, 2021.
Article
in English
| MEDLINE | ID: covidwho-1091860
ABSTRACT
BACKGROUND AND AIMS:
Corona virus disease 2019 (COVID-19) has been an extremely difficult pandemic to contain and it has affected more than 148 countries worldwide. The main aim of this systematic review is to provide a comprehensive summary of clinical and laboratory parameters that are associated with and indicative of increased severity among COVID-19 patients. MATERIAL ANDMETHODS:
All the available data from high-quality research articles relevant to the epidemiology, demographics, trends in hospitalization and outcomes, clinical signs and symptoms, diagnostic methods and treatment methods of COVID-19 were retrieved and evaluated for inclusion.RESULTS:
As per our review, the mean age of patients in the severe group was 59.3 years compared to 46.5 years in non severe group. COVID-19 was more severe among men than women. Clinical presentation was variable among different studies. and dyspnea was the factor indicating severe disease. Laboratory parameters associated with increased severity were lymphopenia <0.8 × 109/L, thrombocytopenia 100 × 109/L, leucocytosis TC > 11 × 109/L, procalcitonin >0.5 ng/mL, d dimer >2 mcg/mL, aspartate transaminase elevation >150U/L, LDH >250U/L.CONCLUSION:
This systematic review suggests that COVID-19 is a disease with varied clinical presentation and laboratory parameters. The commonest clinical symptoms were fever, cough and dyspnea. The laboratory parameters associated with severe disease were lymphopenia, elevated LDH, D dimer and Procalcitonin.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Aspartate Aminotransferases
/
Thrombocytopenia
/
Fibrin Fibrinogen Degradation Products
/
Procalcitonin
/
COVID-19
/
L-Lactate Dehydrogenase
/
Leukocytosis
/
Lymphopenia
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
/
Reviews
/
Systematic review/Meta Analysis
Limits:
Humans
Language:
English
Journal:
Diabetes Metab Syndr
Year:
2021
Document Type:
Article
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