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Serum and CSF alpha-synuclein levels do not change in COVID-19 patients with neurological symptoms.
Blanco-Palmero, V A; Azcárate-Díaz, F J; Ruiz-Ortiz, M; Laespada-García, M I; Rábano-Suárez, P; Méndez-Guerrero, A; Aramendi-Ramos, M; Eguiburu, J L; Pérez-Rivilla, A; Marchán-López, A; Rubio-Fernández, M; Carro, E; González de la Aleja, J.
  • Blanco-Palmero VA; Department of Neurology, Hospital Universitario 12 de Octubre, Avda. de Córdoba, s/n 28041, Madrid, Spain. victorantonio.blanco@salud.madrid.org.
  • Azcárate-Díaz FJ; Group of Neurodegenerative Diseases, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain. victorantonio.blanco@salud.madrid.org.
  • Ruiz-Ortiz M; Networked Biomedical Research Center in Neurodegenerative Diseases (CIBERNED), Madrid, Spain. victorantonio.blanco@salud.madrid.org.
  • Laespada-García MI; Department of Neurology, Hospital Universitario 12 de Octubre, Avda. de Córdoba, s/n 28041, Madrid, Spain.
  • Rábano-Suárez P; Department of Neurology, Hospital Universitario 12 de Octubre, Avda. de Córdoba, s/n 28041, Madrid, Spain.
  • Méndez-Guerrero A; Department of Neurology, Hospital Universitario 12 de Octubre, Avda. de Córdoba, s/n 28041, Madrid, Spain.
  • Aramendi-Ramos M; Department of Neurology, Hospital Universitario 12 de Octubre, Avda. de Córdoba, s/n 28041, Madrid, Spain.
  • Eguiburu JL; Department of Neurology, Hospital Universitario 12 de Octubre, Avda. de Córdoba, s/n 28041, Madrid, Spain.
  • Pérez-Rivilla A; Department of Clinical Analysis, Hospital Universitario 12 de Octubre, Madrid, Spain.
  • Marchán-López A; Department of Clinical Analysis, Hospital Universitario 12 de Octubre, Madrid, Spain.
  • Rubio-Fernández M; Department of Microbiology, Hospital Universitario 12 de Octubre, Madrid, Spain.
  • Carro E; Department of Internal Medicine, Hospital Universitario 12 de Octubre, Madrid, Spain.
  • González de la Aleja J; Group of Neurodegenerative Diseases, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain.
J Neurol ; 268(9): 3116-3124, 2021 Sep.
Article in English | MEDLINE | ID: covidwho-1092071
ABSTRACT
SARS-CoV-2 infection can associate diverse neurological manifestations. Several studies have provided proof to support the theory of neurotropic involvement of SARS-CoV-2. Alpha-synuclein has been described as a native antiviral factor within neurons, and upregulation of this protein can be seen in animals that suffered other neuroinvasive infections. To assess if increased expression of this protein takes place in COVID-19 patients with neurological symptoms, we analyzed serum total alpha-synuclein levels in three groups seven COVID-19 patients with myoclonus, Parkinsonism and/or encephalopathy; thirteen age- and sex-matched COVID-19 patients without neurological involvement and eight age- and sex-matched healthy controls. We did not find differences among them. In a subset of four patients, the change in serum alpha-synuclein before and after the onset of neurological symptoms was not significant either. Cerebrospinal fluid alpha-synuclein levels were also similar between neurological COVID-19 and healthy controls. Overall, these results cannot support the hypothesis of alpha-synuclein upregulation in humans with neurological symptoms in COVID-19. Further research taking into account a larger group of COVID-19 patients including the whole spectrum of neurological manifestations and disease severity is needed.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Brain Diseases / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Animals / Humans Language: English Journal: J Neurol Year: 2021 Document Type: Article Affiliation country: S00415-021-10444-6

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Brain Diseases / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Animals / Humans Language: English Journal: J Neurol Year: 2021 Document Type: Article Affiliation country: S00415-021-10444-6