Coronavirus-Replikation: Mechanismus und Inhibition durch Remdesivir.
Biospektrum (Heidelb)
; 27(1): 49-53, 2021.
Article
in German
| MEDLINE | ID: covidwho-1092773
ABSTRACT
Coronaviruses use an RNA-dependent RNA polymerase to replicate and transcribe their RNA genome. The structure of the SARS-CoV-2 polymerase was determined by cryo-electron microscopy within a short time in spring 2020. The structure explains how the viral enzyme synthesizes RNA and how it replicates the exceptionally large genome in a processive manner. The most recent structure-function studies further reveal the mechanism of polymerase inhibition by remdesivir, an approved drug for the treatment of COVID-19.
Full text:
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Collection:
International databases
Database:
MEDLINE
Language:
German
Journal:
Biospektrum (Heidelb)
Year:
2021
Document Type:
Article
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