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Incidence and impact of disseminated intravascular coagulation in COVID-19 a systematic review and meta-analysis.
Zhou, Xianghui; Cheng, Zhipeng; Luo, Lili; Zhu, Ying; Lin, Wenyi; Ming, Zhangyin; Chen, Wei; Hu, Yu.
  • Zhou X; Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Collaborative Innovation Center of Hematology, Huazhong University of Science and Technology, Wuhan 430022, Hubei, China.
  • Cheng Z; Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Collaborative Innovation Center of Hematology, Huazhong University of Science and Technology, Wuhan 430022, Hubei, China.
  • Luo L; Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Collaborative Innovation Center of Hematology, Huazhong University of Science and Technology, Wuhan 430022, Hubei, China.
  • Zhu Y; Department of Pharmacology, School of Basic Medicine, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022, China.
  • Lin W; Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Collaborative Innovation Center of Hematology, Huazhong University of Science and Technology, Wuhan 430022, Hubei, China.
  • Ming Z; Department of Pharmacology, School of Basic Medicine, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022, China; Tongji-Rongcheng Center for Biomedicine, Huazhong University of Science and Technology, Wuhan 430022, China.
  • Chen W; Laboratory of Vaccine and Antibody Engineering, Beijing Institute of Biotechnology, Beijing 100071, China. Electronic address: cw0226@foxmail.com.
  • Hu Y; Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Collaborative Innovation Center of Hematology, Huazhong University of Science and Technology, Wuhan 430022, Hubei, China; Hubei Clinical Medical Center of Cell Therap
Thromb Res ; 201: 23-29, 2021 05.
Article in English | MEDLINE | ID: covidwho-1093233
ABSTRACT

OBJECTIVES:

Coronavirus disease 2019 (COVID-19) is a novel infectious disease, with significant morbidity and mortality. This meta-analysis is to evaluate the prevalence of disseminated intravascular coagulation (DIC) in COVID-19 patients and to determine the association of DIC with the severity and prognosis of COVID-19.

METHODS:

We searched the PubMed, EMBASE, and China National Knowledge Infrastructure (CNKI) database until August 12, 2020. The meta-analysis was performed using Stata 16.0 software.

RESULTS:

14 studies were included in our meta-analysis. The pooled analysis revealed that the incidence of COVID-19 patients developing DIC was 3% (95% 1%-5%, P < 0.001). In addition, deaths were more likely to be associated with DIC (Log OR = 2.46, 95% CI 0.94-3.99, P < 0.001) with statistical significance.

CONCLUSIONS:

DIC is associated with the severity and poor prognosis of COVID-19 patients. Therefore, attention should be paid to coagulation dysfunction in COVID-19 patients. Monitoring of coagulation indicators may improve the prognosis of COVID-19 inpatients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Disseminated Intravascular Coagulation / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Limits: Humans Country/Region as subject: Asia Language: English Journal: Thromb Res Year: 2021 Document Type: Article Affiliation country: J.thromres.2021.02.010

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Disseminated Intravascular Coagulation / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Limits: Humans Country/Region as subject: Asia Language: English Journal: Thromb Res Year: 2021 Document Type: Article Affiliation country: J.thromres.2021.02.010