Incidence and impact of disseminated intravascular coagulation in COVID-19 a systematic review and meta-analysis.
Thromb Res
; 201: 23-29, 2021 05.
Article
in English
| MEDLINE | ID: covidwho-1093233
ABSTRACT
OBJECTIVES:
Coronavirus disease 2019 (COVID-19) is a novel infectious disease, with significant morbidity and mortality. This meta-analysis is to evaluate the prevalence of disseminated intravascular coagulation (DIC) in COVID-19 patients and to determine the association of DIC with the severity and prognosis of COVID-19.METHODS:
We searched the PubMed, EMBASE, and China National Knowledge Infrastructure (CNKI) database until August 12, 2020. The meta-analysis was performed using Stata 16.0 software.RESULTS:
14 studies were included in our meta-analysis. The pooled analysis revealed that the incidence of COVID-19 patients developing DIC was 3% (95% 1%-5%, P < 0.001). In addition, deaths were more likely to be associated with DIC (Log OR = 2.46, 95% CI 0.94-3.99, P < 0.001) with statistical significance.CONCLUSIONS:
DIC is associated with the severity and poor prognosis of COVID-19 patients. Therefore, attention should be paid to coagulation dysfunction in COVID-19 patients. Monitoring of coagulation indicators may improve the prognosis of COVID-19 inpatients.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Disseminated Intravascular Coagulation
/
COVID-19
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
/
Reviews
/
Systematic review/Meta Analysis
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Thromb Res
Year:
2021
Document Type:
Article
Affiliation country:
J.thromres.2021.02.010
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