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Intravescical instillation of Calmette-Guérin bacillus and COVID-19 risk.
Fedeli, Ugo; Porreca, Angelo; Colicchia, Michele; Schievano, Elena; Artibani, Walter; Biasio, Luigi Roberto; Palù, Giorgio.
  • Fedeli U; Epidemiological Department, Azienda Zero Veneto Region , Padua, Italy.
  • Porreca A; Department of Urology, Policlinico Abano Terme , Padua, Italy.
  • Colicchia M; Department of Urology, Policlinico Abano Terme , Padua, Italy.
  • Schievano E; Epidemiological Department, Azienda Zero Veneto Region , Padua, Italy.
  • Artibani W; Department of Urology, Policlinico Abano Terme , Padua, Italy.
  • Biasio LR; University Contract Lecturer inVaccinology , Rome, Italy.
  • Palù G; Epidemiological Department, Azienda Zero Veneto Region , Padua, Italy.
Hum Vaccin Immunother ; 17(2): 416-417, 2021 Feb 01.
Article in English | MEDLINE | ID: covidwho-1093444
ABSTRACT
It has been theorized that Calmette-Guérin bacillus may prevent or reduce the severity of COVID-19 through a nonspecific stimulation of the immune system. A preliminary assessment of SARS-CoV-2 infection rates and outcomes among 2803 individuals affected with high risk non-muscle-invasive bladder cancer and treated with intra-bladder instillation of BCG, showed no evidence of a protective effect. However, the interpretation of these data need some caution, due to the low prevalence of infection (<1%) observed within this population, along with the fact that intra-bladder administration cannot mirror the usual intradermal administration of BCG, in particular in patients partially immunocompromised. Confirmation by larger prospective studies is required.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: BCG Vaccine / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Vaccines Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Hum Vaccin Immunother Year: 2021 Document Type: Article Affiliation country: 21645515.2020.1805994

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Full text: Available Collection: International databases Database: MEDLINE Main subject: BCG Vaccine / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Vaccines Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Hum Vaccin Immunother Year: 2021 Document Type: Article Affiliation country: 21645515.2020.1805994