MAIT cell activation augments adenovirus vector vaccine immunogenicity.
Science
; 371(6528): 521-526, 2021 01 29.
Article
in English
| MEDLINE | ID: covidwho-1093836
ABSTRACT
Mucosal-associated invariant T (MAIT) cells are innate sensors of viruses and can augment early immune responses and contribute to protection. We hypothesized that MAIT cells may have inherent adjuvant activity in vaccine platforms that use replication-incompetent adenovirus vectors. In mice and humans, ChAdOx1 (chimpanzee adenovirus Ox1) immunization robustly activated MAIT cells. Activation required plasmacytoid dendritic cell (pDC)-derived interferon (IFN)-α and monocyte-derived interleukin-18. IFN-α-induced, monocyte-derived tumor necrosis factor was also identified as a key secondary signal. All three cytokines were required in vitro and in vivo. Activation of MAIT cells positively correlated with vaccine-induced T cell responses in human volunteers and MAIT cell-deficient mice displayed impaired CD8+ T cell responses to multiple vaccine-encoded antigens. Thus, MAIT cells contribute to the immunogenicity of adenovirus vectors, with implications for vaccine design.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Viral Vaccines
/
Adenoviridae
/
Mucosal-Associated Invariant T Cells
/
Immunogenicity, Vaccine
Topics:
Vaccines
Limits:
Animals
/
Humans
Language:
English
Journal:
Science
Year:
2021
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS