Optimization of Analytical Procedure for In-hospital Rapid Quantification of Serum Level of Favipiravir in the Pharmacological Treatment of COVID-19.
Anal Sci
; 37(9): 1301-1304, 2021 Sep 10.
Article
in English
| MEDLINE | ID: covidwho-1094104
ABSTRACT
An in-hospital rapid method for quantifying the serum level of favipiravir (FPV) in the pharmacological treatment of COVID-19 was developed by an appropriate combination of a solid-phase extraction treatment and a reversed-phase HPLC/UV detection system. The quantification method was well-validated and applied to measuring the serum FPV level in a clinical practice at a general hospital that accepts COVID-19 patients. Furthermore, an analysis of data from our preliminary interaction analysis revealed, for the first time, that FPV selectively forms complexes with ferric (Fe3+) and cupric (Cu2+) ions.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pyrazines
/
Blood Chemical Analysis
/
Amides
/
COVID-19 Drug Treatment
/
Hospitals
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Anal Sci
Year:
2021
Document Type:
Article
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