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SARS-CoV-2 Genomes From Oklahoma, United States.
Narayanan, Sai; Ritchey, John C; Patil, Girish; Narasaraju, Teluguakula; More, Sunil; Malayer, Jerry; Saliki, Jeremiah; Kaul, Anil; Agarwal, Pratul K; Ramachandran, Akhilesh.
  • Narayanan S; Oklahoma Animal Disease Diagnostic Laboratory, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK, United States.
  • Ritchey JC; Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK, United States.
  • Patil G; Oklahoma Animal Disease Diagnostic Laboratory, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK, United States.
  • Narasaraju T; Oklahoma Animal Disease Diagnostic Laboratory, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK, United States.
  • More S; Oklahoma Animal Disease Diagnostic Laboratory, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK, United States.
  • Malayer J; Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK, United States.
  • Saliki J; Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK, United States.
  • Kaul A; Oklahoma Animal Disease Diagnostic Laboratory, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK, United States.
  • Agarwal PK; Center for Health Sciences, Oklahoma State University, Tulsa, OK, United States.
  • Ramachandran A; Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK, United States.
Front Genet ; 11: 612571, 2020.
Article in English | MEDLINE | ID: covidwho-1094163
ABSTRACT
Genomic sequencing has played a major role in understanding the pathogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). With the current pandemic, it is essential that SARS-CoV-2 viruses are sequenced regularly to determine mutations and genomic modifications in different geographical locations. In this study, we sequenced SARS-CoV-2 from five clinical samples obtained in Oklahoma, United States during different time points of pandemic presence in the state. One sample from the initial days of the pandemic in the state and four during the peak in Oklahoma were sequenced. Previously reported mutations including D614G in S gene, P4715L in ORF1ab, S194L, R203K, and G204R in N gene were identified in the genomes sequenced in this study. Possible novel mutations were also detected in the S gene (G1167V), ORF1ab (A6269S and P3371S), ORF7b (T28I), and ORF8 (G96R). Phylogenetic analysis of the genomes showed similarity to other SARS-CoV-2 viruses reported from across the globe. Structural characterization indicates that the mutations in S gene possibly influences conformational flexibility and motion of the spike protein, and the mutations in N gene are associated with disordered linker region within the nucleocapsid protein.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Front Genet Year: 2020 Document Type: Article Affiliation country: Fgene.2020.612571

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Front Genet Year: 2020 Document Type: Article Affiliation country: Fgene.2020.612571