Blue photobiomodulation LED therapy impacts SARS-CoV-2 by limiting its replication in Vero cells.
J Biophotonics
; 14(4): e202000496, 2021 04.
Article
in English
| MEDLINE | ID: covidwho-1095310
ABSTRACT
The study of any intervention able to counteract SARS-CoV-2 pandemic is considerably envisaged. It was previously shown, in in vitro models of infections, that the LED blue light is able to decrease the viral load of HSV-1 and ZIKV. In our study, LED photobiomodulation therapy (PBMT) at blue wavelengths (450, 454 and 470 nm) was tested in an in vitro model of SARS-CoV-2 infection, employing three experimental settings SARS-CoV-2 was irradiated and then transferred to cells; already infected cells were irradiated; cells were irradiated prior to infection. A decrement of the viral load was observed when previously infected cells were irradiated with all three tested wavelengths and relevant effects were registered especially at 48 hours post-infection, possibly suggesting that the blue light could interfere with the intracellular viral replication machinery. Our in vitro findings could represent the starting point for translational applications of PBMT as a supportive approach to fight SARS-CoV-2.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Viral Load
/
Low-Level Light Therapy
/
SARS-CoV-2
Type of study:
Experimental Studies
Limits:
Animals
Language:
English
Journal:
J Biophotonics
Journal subject:
Biophysics
Year:
2021
Document Type:
Article
Affiliation country:
Jbio.202000496
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