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Impact of the influenza vaccine on COVID-19 infection rates and severity.
Conlon, Anna; Ashur, Carmel; Washer, Laraine; Eagle, Kim A; Hofmann Bowman, Marion A.
  • Conlon A; University of Michigan School of Medicine, Ann Arbor, MI.
  • Ashur C; Department of Internal Medicine, University of Michigan, Michigan Medicine, Ann Arbor, MI. Electronic address: acarmel@med.umich.edu.
  • Washer L; Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI; Department of Infection Prevention and Epidemiology, Michigan Medicine, Ann Arbor, MI.
  • Eagle KA; Division of Cardiology, Department of Internal Medicine, University of Michigan, Michigan Medicine, Ann Arbor, MI.
  • Hofmann Bowman MA; Division of Cardiology, Department of Internal Medicine, University of Michigan, Michigan Medicine, Ann Arbor, MI.
Am J Infect Control ; 49(6): 694-700, 2021 06.
Article in English | MEDLINE | ID: covidwho-1095799
ABSTRACT

BACKGROUND:

With a unique influenza season occurring in the midst of a pandemic, there is interest in assessing the role of the influenza vaccine in COVID-19 susceptibility and severity.

METHODS:

In this retrospective cohort study, patients receiving a laboratory test for COVID-19 were identified. The primary outcome was comparison of positive COVID-19 testing in those who received the influenza vaccine versus those who did not. Secondary end points in patients testing positive for COVID-19 included mortality, need for hospitalization, length of stay, need for intensive care, and mechanical ventilation.

RESULTS:

A total of 27,201 patients received laboratory testing for COVID-19. The odds of testing positive for COVID-19 was reduced in patients who received an influenza vaccine compared to those who did not (odds ratio 0.76, 95% CI 0.68-0.86; P < .001). Vaccinated patients testing positive for COVID-19 were less likely to require hospitalization (odds ratio, 0.58, 95% CI 0.46-0.73; P < .001), or mechanical ventilation (odds ratio, 0.45, 95% CI 0.27-0.78; P = .004) and had a shorter hospital length of stay (risk ratio, 0.76, 95% CI 0.65-0.89; P < .001).

CONCLUSION:

Influenza vaccination is associated with decreased positive COVID-19 testing and improved clinical outcomes and should be promoted to reduce the burden of COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza Vaccines / Influenza, Human / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Am J Infect Control Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza Vaccines / Influenza, Human / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Am J Infect Control Year: 2021 Document Type: Article