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Micronized / ultramicronized palmitoylethanolamide (PEA) as natural neuroprotector against COVID-19 inflammation.
Roncati, Luca; Lusenti, Beatrice; Pellati, Federica; Corsi, Lorenzo.
  • Roncati L; Department of Surgery, Medicine, Dentistry and Morphological Sciences With Interest in Transplantation, Oncology and Regenerative Medicine, Institute of Pathology, University of Modena and Reggio Emilia, Modena, Italy. Electronic address: luca.roncati@unimore.it.
  • Lusenti B; Department of Surgery, Medicine, Dentistry and Morphological Sciences With Interest in Transplantation, Oncology and Regenerative Medicine, Institute of Pathology, University of Modena and Reggio Emilia, Modena, Italy.
  • Pellati F; Department of Life Sciences, Section of Pharmacology, University of Modena and Reggio Emilia, Modena, Italy.
  • Corsi L; Department of Life Sciences, Section of Pharmacology, University of Modena and Reggio Emilia, Modena, Italy.
Prostaglandins Other Lipid Mediat ; 154: 106540, 2021 06.
Article in English | MEDLINE | ID: covidwho-1096205
ABSTRACT
Coronavirus Disease 2019 (COVID-19) is upsetting the world and innovative therapeutic solutions are needed in an attempt to counter this new pandemic. Great hope lies in vaccines, but drugs to cure the infected patient are just as necessary. In the most severe forms of the disease, a cytokine storm with neuroinflammation occurs, putting the patient's life at serious risk, with sometimes long-lasting sequelae. Palmitoylethanolamide (PEA) is known to possess anti-inflammatory and neuroprotective properties, which make it an ideal candidate to be assumed in the earliest stage of the disease. Here, we provide a mini-review on the topic, pointing out phospholipids consumption in COVID-19, the possible development of an antiphospholipid syndrome secondary to SARS-CoV-2 infection, and reporting our preliminary single-case experience concerning to a 45-year-old COVID-19 female patient recently treated with success by micronized / ultramicronized PEA.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Palmitic Acids / Antiphospholipid Syndrome / Neuroprotective Agents / Ethanolamines / Amides / SARS-CoV-2 / COVID-19 Drug Treatment / Anti-Inflammatory Agents Type of study: Case report / Prognostic study Topics: Long Covid / Vaccines Limits: Female / Humans / Middle aged Language: English Journal: Prostaglandins Other Lipid Mediat Journal subject: Endocrinology Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Palmitic Acids / Antiphospholipid Syndrome / Neuroprotective Agents / Ethanolamines / Amides / SARS-CoV-2 / COVID-19 Drug Treatment / Anti-Inflammatory Agents Type of study: Case report / Prognostic study Topics: Long Covid / Vaccines Limits: Female / Humans / Middle aged Language: English Journal: Prostaglandins Other Lipid Mediat Journal subject: Endocrinology Year: 2021 Document Type: Article