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The peak levels of highly sensitive troponin I predicts in-hospital mortality in COVID-19 patients with cardiac injury: a retrospective study.
Wang, Yaxin; Shu, Huaqing; Liu, Hong; Li, Xia; Zhou, Xing; Zou, Xiaojing; Pan, Shangwen; Xu, Jiqian; Xu, Dan; Zhao, Xin; Yang, Xiaobo; Yu, Yuan; Yuan, Yin; Qi, Hong; Wang, Qiongya; Shang, You.
  • Wang Y; Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Ave, Wuhan, 430022 Hubei, China.
  • Shu H; Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Ave, Wuhan, 430022 Hubei, China.
  • Liu H; Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Ave, Wuhan, 430022 Hubei, China.
  • Li X; Research Center for Translational Medicine, Jinyintan Hospital, No. 1, Yintan Ave, Wuhan, 430012 Hubei, China.
  • Zhou X; Research Center for Translational Medicine, Jinyintan Hospital, No. 1, Yintan Ave, Wuhan, 430012 Hubei, China.
  • Zou X; Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Ave, Wuhan, 430022 Hubei, China.
  • Pan S; Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Ave, Wuhan, 430022 Hubei, China.
  • Xu J; Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Ave, Wuhan, 430022 Hubei, China.
  • Xu D; Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Ave, Wuhan, 430022 Hubei, China.
  • Zhao X; Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Ave, Wuhan, 430022 Hubei, China.
  • Yang X; Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Ave, Wuhan, 430022 Hubei, China.
  • Yu Y; Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Ave, Wuhan, 430022 Hubei, China.
  • Yuan Y; Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Ave, Wuhan, 430022 Hubei, China.
  • Qi H; Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Ave, Wuhan, 430022 Hubei, China.
  • Wang Q; Research Center for Translational Medicine, Jinyintan Hospital, No. 1, Yintan Ave, Wuhan, 430012 Hubei, China.
  • Shang Y; Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Ave, Wuhan, 430022 Hubei, China.
Eur Heart J Acute Cardiovasc Care ; 10(1): 6-15, 2021 Mar 05.
Article in English | MEDLINE | ID: covidwho-1096511
ABSTRACT

AIMS:

To investigate the association between levels of highly sensitive troponin I (hs-troponin I) and mortality in novel coronavirus disease 2019 (COVID-19) patients with cardiac injury. METHODS AND

RESULTS:

We retrospectively reviewed the medical records of all COVID-19 patients with increased levels of hs-troponin I from two hospitals in Wuhan, China. Demographic information, laboratory test results, cardiac ultrasonographic findings, and electrocardiograms were collected, and their predictive value on in-hospital mortality was explored using multivariable logistic regression. Of 1500 patients screened, 242 COVID-19 patients were enrolled in our study. Their median age was 68 years, and (48.8%) had underlying cardiovascular diseases. One hundred and seventy-six (72.7%) patients died during hospitalization. Multivariable logistic regression showed that C-reactive protein (>75.5 mg/L), D-dimer (>1.5 µg/mL), and acute respiratory distress syndrome were risk factors of mortality, and the peak hs-troponin I levels (>259.4 pg/mL) instead of the hs-troponin I levels at admission was predictor of death. The area under the receiver operating characteristic curve of the peak levels of hs-troponin I for predicting in-hospital mortality was 0.79 (95% confidence interval, 0.73-0.86; sensitivity, 0.80; specificity, 0.72; P < 0.0001).

CONCLUSION:

Our results demonstrated that the risk of in-hospital death among COVID-19 patients with cardiac injury can be predicted by the peak levels of hs-troponin I during hospitalization and was significantly associated with oxygen supply-demand mismatch, inflammation, and coagulation.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Hospital Mortality / Troponin I / COVID-19 / Heart Diseases Type of study: Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Eur Heart J Acute Cardiovasc Care Year: 2021 Document Type: Article Affiliation country: Ehjacc

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Hospital Mortality / Troponin I / COVID-19 / Heart Diseases Type of study: Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Eur Heart J Acute Cardiovasc Care Year: 2021 Document Type: Article Affiliation country: Ehjacc