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The use of aspirin for primary prevention of cardiovascular disease is associated with a lower likelihood of COVID-19 infection.
Merzon, Eugene; Green, Ilan; Vinker, Shlomo; Golan-Cohen, Avivit; Gorohovski, Alessandro; Avramovich, Eva; Frenkel-Morgenstern, Milana; Magen, Eli.
  • Merzon E; Leumit Health Services, Tel-Aviv, Israel.
  • Green I; Department of Family Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Israel.
  • Vinker S; Leumit Health Services, Tel-Aviv, Israel.
  • Golan-Cohen A; Department of Family Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Israel.
  • Gorohovski A; Leumit Health Services, Tel-Aviv, Israel.
  • Avramovich E; Department of Family Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Israel.
  • Frenkel-Morgenstern M; Leumit Health Services, Tel-Aviv, Israel.
  • Magen E; Department of Family Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Israel.
FEBS J ; 288(17): 5179-5189, 2021 09.
Article in English | MEDLINE | ID: covidwho-1096764
ABSTRACT
Acetylsalicylic acid (aspirin) is commonly used for primary and secondary prevention of cardiovascular diseases. Aspirin use is associated with better outcomes among COVID-19 positive patients. We hypothesized that the aspirin use for primary cardiovascular disease prevention might have a protective effect on COVID-19 susceptibility and disease duration. We conducted a retrospective population-based cross-sectional study, utilizing data from the Leumit Health Services database. The proportion of patients treated with aspirin was significantly lower among the COVID-19-positive group, as compared to the COVID-19-negative group [73 (11.03%) vs. 1548 (15.77%); P = 0.001]. Aspirin use was associated with lower likelihood of COVID-19 infection, as compared to nonusers (adjusted OR 0.71 (95% CI, 0.52 to 0.99; P = 0.041). Aspirin users were older (68.06 ± 12.79 vs. 56.63 ± 12.28 years of age; P < 0.001), presented a lower BMI (28.77 ± 5.4 vs. 30.37 ± 4.55; P < 0.0189), and showed higher prevalence of hypertension (56, 76.71%), diabetes (47, 64.38%), and COPD (11, 15.07%) than the aspirin nonusers (151, 25.64%, P < 0.001; 130, 22.07%, P < 0.001; and 43, 7.3%, P = 0.023, respectively). Moreover, COVID-19 disease duration (considered as the time between the first positive and second negative COVID-19 RT-PCR test results) among aspirin users was significantly shorter, as compared to aspirin nonusers (19.8 ± 7.8 vs. 21.9 ± 7.9 P = 0.045). Among hospitalized COVID-positive patients, a higher proportion of surviving subjects were treated with aspirin (20, 19.05%), as opposed to 1 dead subject (14.29%), although this difference was not significant (P = 0.449). In conclusion, we observed an inverse association between the likelihood of COVID-19 infection, disease duration and mortality, and aspirin use for primary prevention.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cardiovascular Diseases / Aspirin / SARS-CoV-2 / COVID-19 Drug Treatment Type of study: Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Aged / Humans / Male / Middle aged Language: English Journal: FEBS J Journal subject: Biochemistry Year: 2021 Document Type: Article Affiliation country: Febs.15784

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cardiovascular Diseases / Aspirin / SARS-CoV-2 / COVID-19 Drug Treatment Type of study: Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Aged / Humans / Male / Middle aged Language: English Journal: FEBS J Journal subject: Biochemistry Year: 2021 Document Type: Article Affiliation country: Febs.15784