Your browser doesn't support javascript.
Association of SARS-CoV-2 Seropositive Antibody Test With Risk of Future Infection.
Harvey, Raymond A; Rassen, Jeremy A; Kabelac, Carly A; Turenne, Wendy; Leonard, Sandy; Klesh, Reyna; Meyer, William A; Kaufman, Harvey W; Anderson, Steve; Cohen, Oren; Petkov, Valentina I; Cronin, Kathy A; Van Dyke, Alison L; Lowy, Douglas R; Sharpless, Norman E; Penberthy, Lynne T.
  • Harvey RA; Aetion, Inc, New York, New York.
  • Rassen JA; Aetion, Inc, New York, New York.
  • Kabelac CA; Aetion, Inc, New York, New York.
  • Turenne W; Aetion, Inc, New York, New York.
  • Leonard S; HealthVerity, Philadelphia, Pennsylvania.
  • Klesh R; HealthVerity, Philadelphia, Pennsylvania.
  • Meyer WA; Quest Diagnostics, Secaucus, New Jersey.
  • Anderson S; LabCorp, Burlington, North Carolina.
  • Cohen O; LabCorp, Burlington, North Carolina.
  • Petkov VI; National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
  • Cronin KA; National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
  • Van Dyke AL; National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
  • Lowy DR; National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
  • Sharpless NE; National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
  • Penberthy LT; National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
JAMA Intern Med ; 181(5): 672-679, 2021 05 01.
Article in English | MEDLINE | ID: covidwho-1098863
ABSTRACT
Importance Understanding the effect of serum antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on susceptibility to infection is important for identifying at-risk populations and could have implications for vaccine deployment.

Objective:

The study purpose was to evaluate evidence of SARS-CoV-2 infection based on diagnostic nucleic acid amplification test (NAAT) among patients with positive vs negative test results for antibodies in an observational descriptive cohort study of clinical laboratory and linked claims data. Design, Setting, and

Participants:

The study created cohorts from a deidentified data set composed of commercial laboratory tests, medical and pharmacy claims, electronic health records, and hospital chargemaster data. Patients were categorized as antibody-positive or antibody-negative according to their first SARS-CoV-2 antibody test in the database. Main Outcomes and

Measures:

Primary end points were post-index diagnostic NAAT results, with infection defined as a positive diagnostic test post-index, measured in 30-day intervals (0-30, 31-60, 61-90, >90 days). Additional measures included demographic, geographic, and clinical characteristics at the time of the index antibody test, including recorded signs and symptoms or prior evidence of coronavirus 2019 (COVID) diagnoses or positive NAAT results and recorded comorbidities.

Results:

The cohort included 3 257 478 unique patients with an index antibody test; 56% were female with a median (SD) age of 48 (20) years. Of these, 2 876 773 (88.3%) had a negative index antibody result, and 378 606 (11.6%) had a positive index antibody result. Patients with a negative antibody test result were older than those with a positive result (mean age 48 vs 44 years). Of index-positive patients, 18.4% converted to seronegative over the follow-up period. During the follow-up periods, the ratio (95% CI) of positive NAAT results among individuals who had a positive antibody test at index vs those with a negative antibody test at index was 2.85 (95% CI, 2.73-2.97) at 0 to 30 days, 0.67 (95% CI, 0.6-0.74) at 31 to 60 days, 0.29 (95% CI, 0.24-0.35) at 61 to 90 days, and 0.10 (95% CI, 0.05-0.19) at more than 90 days. Conclusions and Relevance In this cohort study, patients with positive antibody test results were initially more likely to have positive NAAT results, consistent with prolonged RNA shedding, but became markedly less likely to have positive NAAT results over time, suggesting that seropositivity is associated with protection from infection. The duration of protection is unknown, and protection may wane over time.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Disease Susceptibility / COVID-19 Nucleic Acid Testing / COVID-19 Serological Testing / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: North America Language: English Journal: JAMA Intern Med Year: 2021 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Disease Susceptibility / COVID-19 Nucleic Acid Testing / COVID-19 Serological Testing / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: North America Language: English Journal: JAMA Intern Med Year: 2021 Document Type: Article