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Does Famotidine Reduce the Risk of Progression to Severe Disease, Death, and Intubation for COVID-19 Patients? A Systemic Review and Meta-Analysis.
Sun, Chenyu; Chen, Yue; Hu, Lei; Wu, Yile; Liang, Mingming; Ayaz Ahmed, Mubashir; Bhan, Chandur; Guo, Zhichun; Yang, Hongru; Zuo, Yijing; Yan, Yue; Zhou, Qin.
  • Sun C; Internal Medicine, AMITA Health Saint Joseph Hospital Chicago, 2900 N. Lake Shore Drive, Chicago, IL, 60657, USA. drsunchenyu@yeah.net.
  • Chen Y; Department of Clinical Medicine, School of the First Clinical Medicine, Anhui Medical University, No. 81 Meishan Road, Hefei, 230032, Anhui, People's Republic of China.
  • Hu L; Department of Clinical Medicine, School of the First Clinical Medicine, Anhui Medical University, No. 81 Meishan Road, Hefei, 230032, Anhui, People's Republic of China.
  • Wu Y; Department of Epidemiology and Health Statistics, School of Public, Health Anhui Medical University, No. 81 Meishan Road, Hefei, 230032, Anhui, People's Republic of China.
  • Liang M; Center for Evidence-Based Practice, Anhui Medical University, No. 81 Meishan Road, Hefei, 230032, Anhui, China.
  • Ayaz Ahmed M; Department of Epidemiology and Health Statistics, School of Public, Health Anhui Medical University, No. 81 Meishan Road, Hefei, 230032, Anhui, People's Republic of China.
  • Bhan C; Center for Evidence-Based Practice, Anhui Medical University, No. 81 Meishan Road, Hefei, 230032, Anhui, China.
  • Guo Z; Internal Medicine, AMITA Health Saint Joseph Hospital Chicago, 2900 N. Lake Shore Drive, Chicago, IL, 60657, USA.
  • Yang H; Internal Medicine, AMITA Health Saint Joseph Hospital Chicago, 2900 N. Lake Shore Drive, Chicago, IL, 60657, USA.
  • Zuo Y; Massachusetts College of Pharmacy and Health Sciences, 179 Longwood Ave, Boston, MA, 02115, USA.
  • Yan Y; Massachusetts College of Pharmacy and Health Sciences, 179 Longwood Ave, Boston, MA, 02115, USA.
  • Zhou Q; Massachusetts College of Pharmacy and Health Sciences, 179 Longwood Ave, Boston, MA, 02115, USA.
Dig Dis Sci ; 66(11): 3929-3937, 2021 11.
Article in English | MEDLINE | ID: covidwho-1098958
ABSTRACT

BACKGROUND:

Famotidine was reported to potentially provide benefits to Coronavirus Disease 2019 (COVID-19) patients. However, it remains controversial whether it is effective in treating COVID-19.

AIMS:

This study aimed to explore whether famotidine use is associated with reduced risk of the severity, death, and intubation for COVID-19 patients.

METHODS:

This study was registered on International Prospective Register of Systematic Reviews (PROSPERO) (ID CRD42020213536). A comprehensive search was performed to identify relevant studies up to October 2020. I-squared statistic and Q-test were utilized to assess the heterogeneity. Pooled risk ratios (RR) and 95% confidence intervals (CI) were calculated through the random effects or fixed effects model according to the heterogeneity. Subgroup analyses, sensitivity analysis, and publication bias assessment were also conducted.

RESULTS:

Five studies including 36,635 subjects were included. We found that famotidine use was associated with a statistically non-significant reduced risk of progression to severe disease, death, and intubation for Coronavirus Disease 2019 (COVID-19) patients (pooled RR was 0.82, 95% CI = 0.52-1.30, P = 0.40).

CONCLUSION:

Famotidine has no significant protective effect in reducing the risk of developing serious illness, death, and intubation for COVID-19 patients. More original studies are needed to further clarify whether it is associated with reduced risk of the severity, death, and intubation for COVID-19 patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Famotidine / SARS-CoV-2 / COVID-19 / COVID-19 Drug Treatment / Intubation, Intratracheal Type of study: Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: Dig Dis Sci Year: 2021 Document Type: Article Affiliation country: S10620-021-06872-z

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Famotidine / SARS-CoV-2 / COVID-19 / COVID-19 Drug Treatment / Intubation, Intratracheal Type of study: Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: Dig Dis Sci Year: 2021 Document Type: Article Affiliation country: S10620-021-06872-z