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Chloroquine for treatment of COVID-19 results in subtherapeutic exposure and prolonged QTc intervals.
Brüggemann, R J; Moes, D J A R; van Rhee, K P; van 't Veer, N E; Koch, B C P; van Rossum, M; Windsant-van den Tweel, A Vermeulen; Reijers, M H E; van Kimmenade, R R J; Rahamat-Langedoen, J C; Rettig, T C D; van Raalte, R; van Paassen, J; Polderman, F N; van der Linden, P D; Frenzel, T; de Mast, Q; Burger, D M; Schouten, J; van de Veerdonk, F L; Pickkers, P; Ter Heine, R.
  • Brüggemann RJ; Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Pharmacy, Nijmegen, The Netherlands.
  • Moes DJAR; Leiden University Medical Center, Department of Clinical Pharmacy and Toxicology, Leiden, The Netherlands. Electronic address: d.j.a.r.moes@lumc.nl.
  • van Rhee KP; Tergooi Hospital, Department of Clinical Pharmacy, Hilversum, The Netherlands. Electronic address: kvanrhee@tergooi.nl.
  • van 't Veer NE; Department of Clinical Pharmacy, Amphia hospital, Breda, The Netherlands. Electronic address: 0000-0003-1312-8495NvtVeer@amphia.nl.
  • Koch BCP; Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands. Electronic address: b.c.p.koch@erasmusmc.nl.
  • van Rossum M; Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Pharmacy, Nijmegen, The Netherlands. Electronic address: mara.vanrossum@radboudumc.nl.
  • Windsant-van den Tweel AV; Jeroen Bosch Hospital, Department of Pharmacy, 's Hertogenbosch, The Netherlands. Electronic address: A.Vermeulenwindsant@jbz.nl.
  • Reijers MHE; Radboud University Medical Center, Department of Pulmonary Diseases, Nijmegen, The Netherlands. Electronic address: Monique.Reijers@radboudumc.nl.
  • van Kimmenade RRJ; Department of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: Roland.vanKimmenade@radboudumc.nl.
  • Rahamat-Langedoen JC; Radboud Institute for Molecular Life Sciences, Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: Janette.Rahamat-Langedoen@radboudumc.nl.
  • Rettig TCD; Department of Intensive Care and Pain Medicine, Amphia hospital, Breda, The Netherlands. Electronic address: Trettig@amphia.nl.
  • van Raalte R; Department of Intensive Care, Tergooi Hospital, Hilversum, The Netherlands. Electronic address: RvanRaalte@tergooi.nl.
  • van Paassen J; Department of Intensive Care Medicine, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: J.van_Paassen@lumc.nl.
  • Polderman FN; Jeroen Bosch Hospital, Department of Intensive Care, 's Hertogenbosch, The Netherlands. Electronic address: f.polderman@jbz.nl.
  • van der Linden PD; Department of Clinical Pharmacy, Tergooi Hospital, Hilversum, The Netherlands. Electronic address: pvanderlinden@tergooi.nl.
  • Frenzel T; Radboud university medical center, Radboud Institute for Health Sciences, Department of Intensive Care, Nijmegen, The Netherlands. Electronic address: Tim.Frenzel@radboudumc.nl.
  • de Mast Q; Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands. Electronic address: Quirijn.deMast@radboudumc.nl.
  • Burger DM; Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Pharmacy, Nijmegen, The Netherlands. Electronic address: David.Burger@radboudumc.nl.
  • Schouten J; Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Intensive Care, Nijmegen, The Netherlands. Electronic address: Jeroen.schouten@radboudumc.nl.
  • van de Veerdonk FL; Department of Internal Medicine, Radboudumc, Nijmegen, The Netherlands. Electronic address: 0000-0002-1121-4894Frank.vandeVeerdonk@radboudumc.nl.
  • Pickkers P; Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Intensive Care, Nijmegen, The Netherlands. Electronic address: peter.pickkers@radboudumc.nl.
  • Ter Heine R; Radboud University Medical Center, Radboud Institute for Health Sciences, Department of Pharmacy, Nijmegen, The Netherlands. Electronic address: R.terHeine@radboudumc.nl.
Int J Antimicrob Agents ; 57(3): 106293, 2021 Mar.
Article in English | MEDLINE | ID: covidwho-1099125
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Long QT Syndrome / Chloroquine / COVID-19 Drug Treatment Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Int J Antimicrob Agents Year: 2021 Document Type: Article Affiliation country: J.ijantimicag.2021.106293

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Long QT Syndrome / Chloroquine / COVID-19 Drug Treatment Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Int J Antimicrob Agents Year: 2021 Document Type: Article Affiliation country: J.ijantimicag.2021.106293