Your browser doesn't support javascript.
The Activin/Follistatin Axis Is Severely Deregulated in COVID-19 and Independently Associated With In-Hospital Mortality.
Synolaki, Evgenia; Papadopoulos, Vasileios; Divolis, Georgios; Tsahouridou, Olga; Gavriilidis, Efstratios; Loli, Georgia; Gavriil, Ariana; Tsigalou, Christina; Tziolos, Nikolaos R; Sertaridou, Eleni; Kalra, Bhanu; Kumar, Ajay; Rafailidis, Petros; Pasternack, Arja; Boumpas, Dimitrios T; Germanidis, Georgios; Ritvos, Olli; Metallidis, Simeon; Skendros, Panagiotis; Sideras, Paschalis.
  • Synolaki E; Biomedical Research Foundation Academy of Athens, Center for Clinical, Experimental Surgery and Translational Research, Athens, Greece.
  • Papadopoulos V; First Department of Internal Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.
  • Divolis G; Biomedical Research Foundation Academy of Athens, Center for Clinical, Experimental Surgery and Translational Research, Athens, Greece.
  • Tsahouridou O; First Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
  • Gavriilidis E; First Department of Internal Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.
  • Loli G; First Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
  • Gavriil A; Biomedical Research Foundation Academy of Athens, Center for Clinical, Experimental Surgery and Translational Research, Athens, Greece.
  • Tsigalou C; Laboratory of Microbiology, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.
  • Tziolos NR; Fourth Department of Internal Medicine, Attikon University Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
  • Sertaridou E; Intensive Care Unit, University Hospital of Alexandroupolis, Alexandroupolis, Greece.
  • Kalra B; Ansh Labs, Webster, Texas, USA.
  • Kumar A; Ansh Labs, Webster, Texas, USA.
  • Rafailidis P; Second Department of Internal Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.
  • Pasternack A; Department of Physiology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Boumpas DT; Fourth Department of Internal Medicine, Attikon University Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
  • Germanidis G; First Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
  • Ritvos O; Department of Physiology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Metallidis S; First Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
  • Skendros P; First Department of Internal Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.
  • Sideras P; Laboratory of Molecular Hematology, Democritus University of Thrace, Alexandroupolis, Greece.
J Infect Dis ; 223(9): 1544-1554, 2021 05 20.
Article in English | MEDLINE | ID: covidwho-1099601
ABSTRACT

BACKGROUND:

Activins are members of the transforming growth factor-ß superfamily implicated in the pathogenesis of several immunoinflammatory disorders. Based on our previous studies demonstrating that overexpression of activin-A in murine lung causes pathology sharing key features of coronavirus disease 2019 (COVID-19), we hypothesized that activins and their natural inhibitor follistatin might be particularly relevant to COVID-19 pathophysiology.

METHODS:

Activin-A, activin-B, and follistatin were retrospectively analyzed in 574 serum samples from 263 COVID-19 patients hospitalized in 3 independent centers, and compared with demographic, clinical, and laboratory parameters. Optimal scaling with ridge regression was used to screen variables and establish a prediction model.

RESULT:

The activin/follistatin axis was significantly deregulated during the course of COVID-19, correlated with severity and independently associated with mortality. FACT-CLINYCoD, a scoring system incorporating follistatin, activin-A, activin-B, C-reactive protein, lactate dehydrogenase, intensive care unit admission, neutrophil/lymphocyte ratio, age, comorbidities, and D-dimers, efficiently predicted fatal outcome (area under the curve [AUC], 0.951; 95% confidence interval, .919-.983; P <10-6). Two validation cohorts indicated similar AUC values.

CONCLUSIONS:

This study demonstrates a link between activin/follistatin axis and COVID-19 mortality and introduces FACT-CLINYCoD, a novel pathophysiology-based tool that allows dynamic prediction of disease outcome, supporting clinical decision making.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Activins / Follistatin / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: J Infect Dis Year: 2021 Document Type: Article Affiliation country: Infdis

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Activins / Follistatin / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: J Infect Dis Year: 2021 Document Type: Article Affiliation country: Infdis