Inflammatory Cytokine Patterns Associated with Neurological Diseases in Coronavirus Disease 2019.
Ann Neurol
; 89(5): 1041-1045, 2021 05.
Article
in English
| MEDLINE | ID: covidwho-1100843
ABSTRACT
Patients with coronavirus disease 2019 (COVID-19) can present with distinct neurological manifestations. This study shows that inflammatory neurological diseases were associated with increased levels of interleukin (IL)-2, IL-4, IL-6, IL-10, IL-12, chemokine (C-X-C motif) ligand 8 (CXCL8), and CXCL10 in the cerebrospinal fluid. Conversely, encephalopathy was associated with high serum levels of IL-6, CXCL8, and active tumor growth factor ß1. Inflammatory syndromes of the central nervous system in COVID-19 can appear early, as a parainfectious process without significant systemic involvement, or without direct evidence of severe acute respiratory syndrome coronavirus 2 neuroinvasion. At the same time, encephalopathy is mainly influenced by peripheral events, including inflammatory cytokines. ANN NEUROL 2021;891041-1045.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Inflammation Mediators
/
COVID-19
/
Nervous System Diseases
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Ann Neurol
Year:
2021
Document Type:
Article
Affiliation country:
Ana.26041
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