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Clinical Outcomes of Patients Hospitalized with Coronavirus Disease 2019 (COVID-19) in Boston.
El-Jawahri, Areej; Bohossian, Hacho B; Paasche-Orlow, Michael K; Lakin, Joshua R; Johnson, P Connor; Cooper, Zara; Jagielo, Annemarie D; Brannen, Elise N; Reynolds, Matthew J; Coogan, Kathleen; Vaughn, Dagny; Volandes, Angelo.
  • El-Jawahri A; Department of Hematology Oncology, Massachusetts General Hospital, Boston, MA, USA. ael-jawahri@partners.org.
  • Bohossian HB; Harvard Medical School, Boston, MA, USA. ael-jawahri@partners.org.
  • Paasche-Orlow MK; Newton-Wellesley Hospital, Newton, MA, USA.
  • Lakin JR; Tufts University School of Medicine, Boston, MA, USA.
  • Johnson PC; Boston Medical Center, Boston, MA, USA.
  • Cooper Z; Boston University School of Medicine, Boston, MA, USA.
  • Jagielo AD; Harvard Medical School, Boston, MA, USA.
  • Brannen EN; Dana Farber Cancer Institute, Boston, MA, USA.
  • Reynolds MJ; Department of Hematology Oncology, Massachusetts General Hospital, Boston, MA, USA.
  • Coogan K; Harvard Medical School, Boston, MA, USA.
  • Vaughn D; Harvard Medical School, Boston, MA, USA.
  • Volandes A; Brigham and Women's Hospital, Boston, MA, USA.
J Gen Intern Med ; 36(5): 1285-1291, 2021 05.
Article in English | MEDLINE | ID: covidwho-1100991
ABSTRACT

BACKGROUND:

Outcomes of hospitalized patients with COVID-19 have been described in health systems overwhelmed with a surge of cases. However, studies examining outcomes of patients admitted to hospitals not in crisis are lacking.

OBJECTIVE:

To describe clinical characteristic and outcomes of all patients with COVID-19 who are admitted to hospitals not in crisis, and factors associated with mortality in this population.

DESIGN:

A retrospective analysis

PARTICIPANTS:

In total, 470 consecutive patients with COVID-19 requiring hospitalization in one health system in Boston from January 1, 2020 to April 15, 2020. MAIN

MEASURES:

We collected clinical outcomes during hospitalization including intensive care unit (ICU) admission, receipt of mechanical ventilation, and vasopressors. We utilized multivariable logistic regression models to examine factors associated with mortality. KEY

RESULTS:

A total of 470 patients (median age 66 [range 23-98], 54.0% male) were included. The most common comorbidities were diabetes (38.5%, 181/470) and obesity (41.3%, 194/470). On admission, 41.9% (197/470) of patients were febrile and 60.6% (285/470) required supplemental oxygen. During hospitalization, 37.9% (178/470) were admitted to the ICU, 33.6% (158/470) received mechanical ventilation, 29.4% (138/470) received vasopressors, 16.4% (77/470) reported limitations on their desire for life-sustaining therapies such as intubation and cardiopulmonary resuscitation, and 25.1% (118/470) died. Among those admitted to the ICU (N=178), the median number of days on the ventilator was 10 days (IQR 1-29), and 58.4% (104/178) were discharged alive. Older age (OR=1.04, P<0.001), male sex (OR=2.14, P=0.007), higher comorbidities (OR=1.20, P=0.001), higher lactate dehydrogenase on admission (2nd tertile OR=4.07, P<0.001; 3rd tertile OR=8.04, P<0.001), and the need for supplemental oxygen on admission (OR=2.17, P=0.014) were all associated with higher mortality.

CONCLUSIONS:

The majority of hospitalized patients with COVID-19 and those who received mechanical ventilation survived. These data highlight the need to examine public health and system factors that contribute to improved outcomes for this population.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Prognostic study Limits: Aged / Female / Humans / Male Country/Region as subject: North America Language: English Journal: J Gen Intern Med Journal subject: Internal Medicine Year: 2021 Document Type: Article Affiliation country: S11606-021-06622-x

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Prognostic study Limits: Aged / Female / Humans / Male Country/Region as subject: North America Language: English Journal: J Gen Intern Med Journal subject: Internal Medicine Year: 2021 Document Type: Article Affiliation country: S11606-021-06622-x