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CIGB-258, a peptide derived from human heat-shock protein 60, decreases hyperinflammation in COVID-19 patients.
Hernandez-Cedeño, M; Venegas-Rodriguez, R; Peña-Ruiz, R; Bequet-Romero, M; Santana-Sanchez, R; Penton-Arias, E; Martinez-Donato, G; Guillén-Nieto, G; Dominguez-Horta, María Del Carmen.
  • Hernandez-Cedeño M; Biomedical Research Department, Center for Genetic Engineering and Biotechnology, P.O. Box 6162, 11300, Havana, Cuba.
  • Venegas-Rodriguez R; Luis Díaz Soto Hospital, Avenida Monumental km 2, Habana del Este, Havana, Cuba.
  • Peña-Ruiz R; Luis Díaz Soto Hospital, Avenida Monumental km 2, Habana del Este, Havana, Cuba.
  • Bequet-Romero M; Biomedical Research Department, Center for Genetic Engineering and Biotechnology, P.O. Box 6162, 11300, Havana, Cuba.
  • Santana-Sanchez R; Luis Díaz Soto Hospital, Avenida Monumental km 2, Habana del Este, Havana, Cuba.
  • Penton-Arias E; Biomedical Research Department, Center for Genetic Engineering and Biotechnology, P.O. Box 6162, 11300, Havana, Cuba.
  • Martinez-Donato G; Biomedical Research Department, Center for Genetic Engineering and Biotechnology, P.O. Box 6162, 11300, Havana, Cuba.
  • Guillén-Nieto G; Biomedical Research Department, Center for Genetic Engineering and Biotechnology, P.O. Box 6162, 11300, Havana, Cuba.
  • Dominguez-Horta MDC; Biomedical Research Department, Center for Genetic Engineering and Biotechnology, P.O. Box 6162, 11300, Havana, Cuba. mcarmen.dominguez@cigb.edu.cu.
Cell Stress Chaperones ; 26(3): 515-525, 2021 05.
Article in English | MEDLINE | ID: covidwho-1101014
ABSTRACT
Hyperinflammation distinguishes COVID-19 patients who develop a slight disease or none, from those progressing to severe and critical conditions. CIGB-258 is a therapeutic option for the latter group of patients. This drug is an altered peptide ligand (APL) derived from the cellular stress protein 60 (HSP60). In preclinical models, this peptide developed anti-inflammatory effects and increased regulatory T cell (Treg) activity. Results from a phase I clinical trial with rheumatoid arthritis (RA) patients indicated that CIGB-258 was safe and reduced inflammation. The aim of this study was to examine specific biomarkers associated with hyperinflammation, some cytokines linked to the cytokine storm granzyme B and perforin in a cohort of COVID-19 patients treated with this peptide. All critically ill patients were under invasive mechanical ventilation and received the intravenous administration of 1 or 2 mg of CIGB-258 every 12 h. Seriously ill patients were treated with oxygen therapy receiving 1 mg of CIGB-258 every 12 h and all patients recovered from their severe condition. Biomarker levels associated with hyperinflammation, such as interleukin (IL)-6, IL-10, tumor necrosis factor (TNF-α), granzyme B, and perforin, significantly decreased during treatment. Furthermore, we studied the ability of CIGB-258 to induce Tregs in COVID-19 patients and found that Tregs were induced in all patients studied. Altogether, these results support the therapeutic potential of CIGB-258 for diseases associated with hyperinflammation. Clinical trial registry RPCEC00000313.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Chaperonin 60 / Cytokine Release Syndrome / COVID-19 Drug Treatment / Anti-Inflammatory Agents Type of study: Cohort study / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Cell Stress Chaperones Year: 2021 Document Type: Article Affiliation country: S12192-021-01197-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Chaperonin 60 / Cytokine Release Syndrome / COVID-19 Drug Treatment / Anti-Inflammatory Agents Type of study: Cohort study / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Cell Stress Chaperones Year: 2021 Document Type: Article Affiliation country: S12192-021-01197-2