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Correlation of Krebs von den Lungen-6 and fibronectin with pulmonary fibrosis in coronavirus disease 2019.
Peng, Ding-Hui; Luo, Yi; Huang, Li-Jun; Liao, Fan-Lu; Liu, Yan-Yuan; Tang, Peng; Hu, Han-Ning; Chen, Wei.
  • Peng DH; Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Luo Y; Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Huang LJ; Department of Clinical Laboratory, Huangzhou District People's Hospital, Huanggang, Hubei, China.
  • Liao FL; Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Liu YY; Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Tang P; Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Hu HN; Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China. Electronic address: hhn_2296@163.com.
  • Chen W; Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China. Electronic address: 602400856@qq.com.
Clin Chim Acta ; 517: 48-53, 2021 Jun.
Article in English | MEDLINE | ID: covidwho-1101132
Semantic information from SemMedBD (by NLM)
1. KL-6 analysis DIAGNOSES COVID-19
Subject
KL-6 analysis
Predicate
DIAGNOSES
Object
COVID-19
2. 2019 novel coronavirus CAUSES COVID-19
Subject
2019 novel coronavirus
Predicate
CAUSES
Object
COVID-19
3. Elevation procedure TREATS COVID-19
Subject
Elevation procedure
Predicate
TREATS
Object
COVID-19
4. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
5. Elevation procedure TREATS Patients
Subject
Elevation procedure
Predicate
TREATS
Object
Patients
6. KL-6 analysis DIAGNOSES COVID-19
Subject
KL-6 analysis
Predicate
DIAGNOSES
Object
COVID-19
7. 2019 novel coronavirus CAUSES COVID-19
Subject
2019 novel coronavirus
Predicate
CAUSES
Object
COVID-19
8. Elevation procedure TREATS COVID-19
Subject
Elevation procedure
Predicate
TREATS
Object
COVID-19
9. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
10. Elevation procedure TREATS Patients
Subject
Elevation procedure
Predicate
TREATS
Object
Patients
ABSTRACT

OBJECTIVE:

Coronavirus Disease 2019 (COVID-19) caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still spreading worldwide, which may progress to pulmonary fibrosis (PF), leading to the worsen outcome. As the markers of lung injury, the correlation of Krebs von den Lungen-6 (KL-6) and fibronectin (Fn) with pulmonary fibrosis in COVID-19 was still unclear.

METHODS:

113 patients diagnosed as COVID-19 were enrolled in this retrospective study, and divided into three categories as mild, moderate and severe cases. The concentrations of serum KL-6 and Fn at hospital admission were tested using the method of latex agglutination assay and immunoturbidimetic assay, respectively.

RESULTS:

Compared with that in the non-severe COVID-19 cases and normal control subjects, serum KL-6 concentration on admission was significantly higher in the severe group, which was positively correlated with C-reactive protein, and negatively correlated with lymphocytes count. Whereas, no obvious elevation in serum Fn concentration was investigated in COVID-19 patients with the different phenotypes. The severe cases displayed the higher incident rate of pulmonary fibrosis at hospital discharge. Compared with non-PF patients, the COVID-19 cases with PF had the higher serum KL-6 values.

CONCLUSION:

Serum KL-6 concentration was significantly elevated in severe COVID-19 patients, which may be useful for evaluating the disease severity. For early prevention of the development of pulmonary fibrosis, high concentrations of serum KL-6 in the early stage of COVID-19 should be paid close attention.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pulmonary Fibrosis / Fibronectins / Mucin-1 / COVID-19 Type of study: Diagnostic study / Observational study Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Clin Chim Acta Year: 2021 Document Type: Article Affiliation country: J.cca.2021.02.012

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pulmonary Fibrosis / Fibronectins / Mucin-1 / COVID-19 Type of study: Diagnostic study / Observational study Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Clin Chim Acta Year: 2021 Document Type: Article Affiliation country: J.cca.2021.02.012