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SARS-CoV-2 mediated neuroinflammation and the impact of COVID-19 in neurological disorders.
Amruta, Narayanappa; Chastain, Wesley H; Paz, Meshi; Solch, Rebecca J; Murray-Brown, Isabel C; Befeler, Jaime B; Gressett, Timothy E; Longo, Michele T; Engler-Chiurazzi, Elizabeth B; Bix, Gregory.
  • Amruta N; Department of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA, 70112, USA.
  • Chastain WH; Department of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA, 70112, USA.
  • Paz M; Department of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA, 70112, USA.
  • Solch RJ; Department of Neurology, Tulane University School of Medicine, New Orleans, LA, 70112, USA.
  • Murray-Brown IC; Department of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA, 70112, USA.
  • Befeler JB; Department of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA, 70112, USA.
  • Gressett TE; Department of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA, 70112, USA.
  • Longo MT; Department of Neurology, Tulane University School of Medicine, New Orleans, LA, 70112, USA; Tulane Brain Institute, Tulane University, New Orleans, LA, 70112, USA.
  • Engler-Chiurazzi EB; Department of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA, 70112, USA; Tulane Brain Institute, Tulane University, New Orleans, LA, 70112, USA.
  • Bix G; Department of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA, 70112, USA; Department of Neurology, Tulane University School of Medicine, New Orleans, LA, 70112, USA; Tulane Brain Institute, Tulane University, New Orleans, LA, 70112, USA. El
Cytokine Growth Factor Rev ; 58: 1-15, 2021 04.
Article in English | MEDLINE | ID: covidwho-1101169
ABSTRACT
SARS-CoV-2 is a novel coronavirus that severely affects the respiratory system, is the cause of the COVID-19 pandemic, and is projected to result in the deaths of 2 million people worldwide. Recent reports suggest that SARS-CoV-2 also affects the central nervous system along with other organs. COVID-19-associated complications are observed in older people with underlying neurological conditions like stroke, Alzheimer's disease, and Parkinson's disease. Hence, we discuss SARS-CoV-2 viral replication and its inflammation-mediated infection. This review also focuses on COVID-19 associated neurological complications in individuals with those complications as well as other groups of people. Finally, we also briefly discuss the current therapies available to treat patients, as well as ongoing available treatments and vaccines for effective cures with a special focus on the therapeutic potential of a small 5 amino acid peptide (PHSCN), ATN-161, that inhibits SARS-CoV-2 spike protein binding to both integrin α5ß1 and α5ß1/hACE2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Neurogenic Inflammation / SARS-CoV-2 / COVID-19 / Nervous System Diseases Type of study: Experimental Studies / Observational study / Randomized controlled trials Topics: Long Covid / Vaccines Limits: Aged / Humans Language: English Journal: Cytokine Growth Factor Rev Journal subject: Allergy and Immunology / Biochemistry Year: 2021 Document Type: Article Affiliation country: J.cytogfr.2021.02.002

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Neurogenic Inflammation / SARS-CoV-2 / COVID-19 / Nervous System Diseases Type of study: Experimental Studies / Observational study / Randomized controlled trials Topics: Long Covid / Vaccines Limits: Aged / Humans Language: English Journal: Cytokine Growth Factor Rev Journal subject: Allergy and Immunology / Biochemistry Year: 2021 Document Type: Article Affiliation country: J.cytogfr.2021.02.002