Neurotropic Effects of SARS-CoV-2 Modeled by the Human Brain Organoids.
Stem Cell Reports
; 16(3): 373-384, 2021 03 09.
Article
in English
| MEDLINE | ID: covidwho-1101516
ABSTRACT
COVID-19, caused by SARS-CoV-2, is a socioeconomic burden, which exhibits respiratory illness along with unexpected neurological complications. Concerns have been raised about whether the observed neurological symptoms are due to direct effects on CNS or associated with the virus's systemic effect. Recent SARS-CoV-2 infection studies using human brain organoids revealed that SARS-CoV-2 targets human neurons. Human brain organoids are stem cell-derived reductionist experimental systems that have highlighted the neurotropic effects of SARS-CoV-2. Here, we summarize the neurotoxic effects of SARS-CoV-2 using brain organoids and comprehensively discuss how brain organoids could further improve our understanding when they are fine-tuned.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Brain
/
Organoids
/
SARS-CoV-2
/
COVID-19
/
Neurons
Type of study:
Experimental Studies
Limits:
Humans
Language:
English
Journal:
Stem Cell Reports
Year:
2021
Document Type:
Article
Affiliation country:
J.stemcr.2021.02.007
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