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Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19.
Salguero, Francisco J; White, Andrew D; Slack, Gillian S; Fotheringham, Susan A; Bewley, Kevin R; Gooch, Karen E; Longet, Stephanie; Humphries, Holly E; Watson, Robert J; Hunter, Laura; Ryan, Kathryn A; Hall, Yper; Sibley, Laura; Sarfas, Charlotte; Allen, Lauren; Aram, Marilyn; Brunt, Emily; Brown, Phillip; Buttigieg, Karen R; Cavell, Breeze E; Cobb, Rebecca; Coombes, Naomi S; Darby, Alistair; Daykin-Pont, Owen; Elmore, Michael J; Garcia-Dorival, Isabel; Gkolfinos, Konstantinos; Godwin, Kerry J; Gouriet, Jade; Halkerston, Rachel; Harris, Debbie J; Hender, Thomas; Ho, Catherine M K; Kennard, Chelsea L; Knott, Daniel; Leung, Stephanie; Lucas, Vanessa; Mabbutt, Adam; Morrison, Alexandra L; Nelson, Charlotte; Ngabo, Didier; Paterson, Jemma; Penn, Elizabeth J; Pullan, Steve; Taylor, Irene; Tipton, Tom; Thomas, Stephen; Tree, Julia A; Turner, Carrie; Vamos, Edith.
  • Salguero FJ; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • White AD; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Slack GS; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Fotheringham SA; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Bewley KR; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Gooch KE; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Longet S; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Humphries HE; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Watson RJ; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Hunter L; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Ryan KA; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Hall Y; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Sibley L; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Sarfas C; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Allen L; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Aram M; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Brunt E; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Brown P; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Buttigieg KR; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Cavell BE; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Cobb R; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Coombes NS; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Darby A; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
  • Daykin-Pont O; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Elmore MJ; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Garcia-Dorival I; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
  • Gkolfinos K; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Godwin KJ; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Gouriet J; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Halkerston R; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Harris DJ; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Hender T; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Ho CMK; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Kennard CL; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Knott D; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Leung S; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Lucas V; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Mabbutt A; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Morrison AL; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Nelson C; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
  • Ngabo D; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Paterson J; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Penn EJ; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Pullan S; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Taylor I; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Tipton T; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Thomas S; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Tree JA; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Turner C; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, Wiltshire, UK.
  • Vamos E; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
Nat Commun ; 12(1): 1260, 2021 02 24.
Article in English | MEDLINE | ID: covidwho-1101645
ABSTRACT
A novel coronavirus, SARS-CoV-2, has been identified as the causative agent of the current COVID-19 pandemic. Animal models, and in particular non-human primates, are essential to understand the pathogenesis of emerging diseases and to assess the safety and efficacy of novel vaccines and therapeutics. Here, we show that SARS-CoV-2 replicates in the upper and lower respiratory tract and causes pulmonary lesions in both rhesus and cynomolgus macaques. Immune responses against SARS-CoV-2 are also similar in both species and equivalent to those reported in milder infections and convalescent human patients. This finding is reiterated by our transcriptional analysis of respiratory samples revealing the global response to infection. We describe a new method for lung histopathology scoring that will provide a metric to enable clearer decision making for this key endpoint. In contrast to prior publications, in which rhesus are accepted to be the preferred study species, we provide convincing evidence that both macaque species authentically represent mild to moderate forms of COVID-19 observed in the majority of the human population and both species should be used to evaluate the safety and efficacy of interventions against SARS-CoV-2. Importantly, accessing cynomolgus macaques will greatly alleviate the pressures on current rhesus stocks.
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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: COVID-19 / Lung Subject: COVID-19 / Lung Type of study: Prognostic study Language: English Journal: Nat Commun Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: COVID-19 / Lung Subject: COVID-19 / Lung Type of study: Prognostic study Language: English Journal: Nat Commun Year: 2021
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