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Monocyte CD169 Expression as a Biomarker in the Early Diagnosis of Coronavirus Disease 2019.
Bedin, Anne-Sophie; Makinson, Alain; Picot, Marie-Christine; Mennechet, Frank; Malergue, Fabrice; Pisoni, Amandine; Nyiramigisha, Esperance; Montagnier, Lise; Bollore, Karine; Debiesse, Ségolène; Morquin, David; Veyrenche, Nicolas; Renault, Constance; Foulongne, Vincent; Bret, Caroline; Bourdin, Arnaud; Le Moing, Vincent; Van de Perre, Philippe; Tuaillon, Edouard.
  • Bedin AS; Pathogenesis and Control of Chronic Infections, Montpellier University, INSERM, EFS, Montpellier, France.
  • Makinson A; INSERM U1175/IRD UMI 233, IRD, Montpellier University, Montpellier, France.
  • Picot MC; Department of Infectious Diseases, Montpellier University Hospital, Montpellier, France.
  • Mennechet F; INSERM, Centre d'Investigation Clinique 1411, Montpellier University, Montpellier, France.
  • Malergue F; Montpellier University Hospital, Montpellier, France.
  • Pisoni A; Pathogenesis and Control of Chronic Infections, Montpellier University, INSERM, EFS, Montpellier, France.
  • Nyiramigisha E; Department of Research and Development, Immunotech-Beckman Coulter, Marseille, France.
  • Montagnier L; Pathogenesis and Control of Chronic Infections, Montpellier University, INSERM, EFS, Montpellier, France.
  • Bollore K; Laboratory of Virology, Montpellier University Hospital, France.
  • Debiesse S; Laboratory of Virology, Montpellier University Hospital, France.
  • Morquin D; Laboratory of Virology, Montpellier University Hospital, France.
  • Veyrenche N; Pathogenesis and Control of Chronic Infections, Montpellier University, INSERM, EFS, Montpellier, France.
  • Renault C; Pathogenesis and Control of Chronic Infections, Montpellier University, INSERM, EFS, Montpellier, France.
  • Foulongne V; Department of Infectious Diseases, Montpellier University Hospital, Montpellier, France.
  • Bret C; Laboratory of Virology, Montpellier University Hospital, France.
  • Bourdin A; Pathogenesis and Control of Chronic Infections, Montpellier University, INSERM, EFS, Montpellier, France.
  • Le Moing V; Pathogenesis and Control of Chronic Infections, Montpellier University, INSERM, EFS, Montpellier, France.
  • Van de Perre P; Laboratory of Virology, Montpellier University Hospital, France.
  • Tuaillon E; Laboratory of Hematology, Montpellier University Hospital, France.
J Infect Dis ; 223(4): 562-567, 2021 02 24.
Article in English | MEDLINE | ID: covidwho-1101848
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ABSTRACT
We assessed the expression of CD169, a type I interferon-inducible receptor, on monocytes (monocyte CD169 [mCD169]) in 53 adult patients admitted to the hospital during the coronavirus disease 2019 (COVID-19) outbreak for a suspicion of severe acute respiratory syndrome coronavirus 2 infection. Monocyte CD169 was strongly overexpressed in 30 of 32 (93.7%) confirmed COVID-19 cases, compared with 3 of 21 (14.3%) patients in whom the diagnosis of COVID-19 was finally ruled out. Monocyte CD169 was associated with the plasma interferon-alpha level and thrombocytopenia. Monocyte CD169 testing may be helpful for the rapid triage of suspected COVID-19 patients during an outbreak.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Monocytes / Sialic Acid Binding Ig-like Lectin 1 / COVID-19 Type of study: Diagnostic study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: J Infect Dis Year: 2021 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Monocytes / Sialic Acid Binding Ig-like Lectin 1 / COVID-19 Type of study: Diagnostic study / Prognostic study Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: J Infect Dis Year: 2021 Document Type: Article Affiliation country: Infdis